Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single-blind placebo-controlled study
Tripeptide gut hormone infusion does not alter food preferences or sweet taste function in volunteers with obesity and prediabetes/diabetes but promotes restraint eating: A secondary analysis of a randomized single-blind placebo-controlled study
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三肽肠道激素输注不会改变肥胖和糖尿病前期/糖尿病志愿者的食物偏好或甜味功能，但会促进限制饮食：随机单盲安慰剂对照研究的二次分析
DOI：
10.1111/dom.15028
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Behary P
中科院分区：
文献类型：
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作者：
Behary P
目的调查肠道激素胰高血糖素样肽-1 (GLP-1)、胃泌酸调节素 (OXM) 和肽 YY (PYY) 的餐后浓度升高是否是 Roux-en-Y 胃绕道手术 (RYGB) 后食物偏好、甜味功能和饮食行为的有益变化的原因。材料和方法这是对一项随机单盲研究的二次分析，在该研究中我们注入了 GLP-1、OXM、在 24 名肥胖和糖尿病前期/糖尿病受试者中皮下注射 PYY (GOP) 或 0.9% 盐水 4 周，以复制其餐后峰值浓度，如在匹配的 RYGB 队列中 1 个月时测量的那样 (ClinicalTrials.gov NCT01945840)。完成了 4 天的饮食日记和经过验证的饮食行为问卷。使用恒定刺激的方法测量甜味检测。记录正确的蔗糖识别（校正的命中率），并从浓度曲线得出甜味检测阈值（EC50：半最大有效浓度值）。使用广义标签量表评估甜味的强度和终极奖励值。结果GOP 期间平均每日能量摄入量减少了 27%，但没有观察到食物偏好的显着变化，而 RYGB 后发现脂肪减少和蛋白质摄入量增加。 GOP 输注后蔗糖检测的校正命中率或检测阈值没有变化。此外，GOP 并没有改变甜味的强度或完成奖励值。与 RYGB 组相比，GOP 组观察到克制饮食显着减少。结论 RYGB 后血浆 GOP 浓度升高不太可能介导手术后食物偏好和甜味功能的变化，但可能促进克制饮食。
AimsTo investigate whether the elevation in postprandial concentrations of the gut hormones glucagon‐like peptide‐1 (GLP‐1), oxyntomodulin (OXM) and peptide YY (PYY) accounts for the beneficial changes in food preferences, sweet taste function and eating behaviour after Roux‐en‐Y gastric bypass (RYGB).Materials and methodsThis was a secondary analysis of a randomized single‐blind study in which we infused GLP‐1, OXM, PYY (GOP) or 0.9% saline subcutaneously for 4 weeks in 24 subjects with obesity and prediabetes/diabetes, to replicate their peak postprandial concentrations, as measured at 1 month in a matched RYGB cohort (ClinicalTrials.gov NCT01945840). A 4‐day food diary and validated eating behaviour questionnaires were completed. Sweet taste detection was measured using the method of constant stimuli. Correct sucrose identification (corrected hit rates) was recorded, and sweet taste detection thresholds (EC50s: half maximum effective concencration values) were derived from concentration curves. The intensity and consummatory reward value of sweet taste were assessed using the generalized Labelled Magnitude Scale.ResultsMean daily energy intake was reduced by 27% with GOP but no significant changes in food preferences were observed, whereas a reduction in fat and increase in protein intake were seen post‐RYGB. There was no change in corrected hit rates or detection thresholds for sucrose detection following GOP infusion. Additionally, GOP did not alter the intensity or consummatory reward value of sweet taste. A significant reduction in restraint eating, comparable to the RYGB group was observed with GOP.ConclusionThe elevation in plasma GOP concentrations after RYGB is unlikely to mediate changes in food preferences and sweet taste function after surgery but may promote restraint eating.