Key Genes and Endoscopic Radical Surgery in Primary Middle Ear Oncocytic Papillomas
Key Genes and Endoscopic Radical Surgery in Primary Middle Ear Oncocytic Papillomas
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DOI：
10.1097/mao.0000000000003993
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发表时间：
2023-10-01
影响因子：
2.1
通讯作者：
Ren，Dongdong
中科院分区：
文献类型：
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作者：
Lyu，Jihan;Wang，Wei;Ren，Dongdong
起源于中耳内的施奈德上皮的乳头状瘤是非常罕见的，并且可能与高复发率和恶性转化有关。嗜酸细胞乳头状瘤是此类肿瘤中最罕见的病理亚型。目前的研究旨在确定是否存在一个独特的机制，发病率的嗜酸性乳头状瘤主要发生在中耳，并探讨潜在的治疗策略，以确保完全切除和防止复发。研究设计搜索英文文献的情况下，中耳乳头状瘤和RNA测序分析的三个样本，从一个新的情况下，在眼科和耳鼻喉医院，复旦大学（中国上海），复发性中耳嗜酸性乳头状瘤，沿着两个正常粘膜样本。
ObjectivePapillomas originating from the Schneiderian epithelium within the middle ear are extremely rare and may be associated with a high rate of recurrence and malignant transformation. Oncocytic papillomas represent the rarest pathological subtype of such tumors. The current investigation aimed to determine whether there exists a distinct mechanism underlying the incidence of oncocytic papillomas arising primarily within the middle ear, and to explore potential treatment strategies to ensure complete removal and prevent recurrence.Study DesignSearch of the English literature for cases of middle ear papilloma and RNA sequencing analysis of three samples from one new case presenting at the Eye and ENT Hospital, Fudan University (Shanghai, China), with recurrent middle ear oncocytic papilloma, along with two normal mucosal samples.Setting