Natural history and prognosis of untreated stage I epithelial ovarian carcinoma
Natural history and prognosis of untreated stage I epithelial ovarian carcinoma
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DOI：
10.1200/jco.1996.14.11.2968
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发表时间：
1996-11-01
影响因子：
45.3
通讯作者：
Gore, ME
中科院分区：
文献类型：
--
作者：
Ahmed, FY;Wiltshaw, E;Gore, ME
目的：本研究的目的是探讨I期浸润性上皮性卵巢癌（EOC）预后因素的独立意义。患者和方法：1980年至1994年，所有I期EOC患者，手术切除后的所有患者（不包括交界性肿瘤）进入本研究，无患者接受辅助治疗，并对患者进行如下监测：1 - 2岁-每3个月进行一次体格检查和血清CA 125，每6个月进行一次计算机断层扫描（CT）; 3 - 5岁-每6个月进行一次体格检查和血清CA 125，每年进行一次CT扫描; 5 - 10岁-每年进行一次体格检查和血清CA 125，如果有临床指征，进行CT扫描。共有194例患者入组研究。中位患者年龄为54岁（范围：15 - 83岁），中位随访时间为54个月（范围：7 - 157个月）。5年生存率如下：IA期，93.7%; IB期，92%; IC期，84%。多因素分析采用考克斯回归确定等级（P
Purpose: The aim of this study was to investigate the independent significance of prognostic factors in stage I invasive epithelial ovarian cancer (EOC).Patients and Methods: Between 1980 and 1994, all patients with stage I EOC (borderline tumors excluded) following surgical resection were entered onto this study, No patient received adjuvant therapy and patients were monitored as follows: years 1 to 2-physical examination and serum CA125 every 3 months and computed tomographic (CT) scan every 6 months; years 3 to 5-physical examination and serum CA 125 every 6 months and CT scan yearly; years 5 to 10-annual physical examination and serum CA125, with CT scan if clinically indicated.Results: A total of 194 patients entered the study. The median patient age was 54 years (range, 15 to 83), and the median follow-up duration 54 months (range, 7 to 157). Five-year survival rates were as follows: stage IA, 93.7%; stage IB, 92%; and stage IC, 84%. Multivariate analysis using Cox's regression identified grade (P