Association between dimensions of trauma-related psychopathology and asthma in trauma-exposed women.
Association between dimensions of trauma-related psychopathology and asthma in trauma-exposed women.
复制标题
DOI：
10.3389/fnbeh.2023.1268877
复制
发表时间：
2023
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
暴露于创伤性事件和紧张的生活经历与各种不利的心理和身体健康结果有关。研究发现，除了哮喘等炎症性疾病外，创伤后应激障碍（PTSD）、抑郁和焦虑敏感性的发生也很常见，尤其是在女性中。此外，重叠的神经生物学机制与创伤后应激障碍和哮喘都有关。在目前的研究中，n = 508名女性报告存在终生哮喘诊断和创伤相关精神病理症状，包括创伤后应激障碍和抑郁症。另一组女性参与者（n = 64）报告了哮喘、创伤后应激障碍、抑郁和焦虑敏感性，并在恐惧面孔任务中接受了功能性MRI扫描，并分析了她们的前脑岛反应。总体而言，哮喘患者的创伤后应激障碍和抑郁严重程度明显高于非哮喘患者。只有在没有终生哮喘病史的个体中，前脑岛对社会威胁线索的反应与抑郁症状之间存在正相关。这些发现为压力、内感受和显著性检测的神经机制以及创伤相关精神病理学之间的相互作用提供了持续的证据。
Exposure to traumatic events and stressful life experiences are associated with a wide range of adverse mental and physical health outcomes. Studies have found post-traumatic stress disorder (PTSD), depression, and anxiety sensitivity occurrence to be common in addition to inflammatory diseases like asthma, especially in women. Moreover, overlapping neurobiological mechanisms have been linked to both PTSD and asthma. In the current study, n = 508 women reported on presence of lifetime asthma diagnosis and symptoms of trauma-related psychopathology including PTSD and depression. A separate group of female participants (n = 64) reported on asthma, PTSD, depression and anxiety sensitivity, and underwent functional MRI scans during a fearful faces task, and their anterior insula responses were analyzed. Overall, PTSD and depression severity were significantly higher in those with asthma versus those without asthma. There was a positive association between anterior insula response to social threat cues and depression symptoms only among individuals without a lifetime presence of asthma. These findings provide continued evidence on the interactions between stress, neural mechanisms involved in interoception and salience detection, and trauma-related psychopathology.
登录
查看更多内容
影响因子：
5.3
作者：
Cattaneo A;Macchi F;Plazzotta G;Veronica B;Bocchio-Chiavetto L;Riva MA;Pariante CM
通讯作者：
Pariante CM
影响因子：
3.1
作者：
Barone, Silvana;Bacon, Simon L.;Lavoie, Kim L.
通讯作者：
Lavoie, Kim L.
影响因子：
5.9
作者：
Eisner, MD;Katz, PP;Iribarren, C
通讯作者：
Iribarren, C
影响因子：
10.6
作者：
Simmons AN;Paulus MP;Thorp SR;Matthews SC;Norman SB;Stein MB
通讯作者：
Stein MB
影响因子：
10.6
作者：
Avery, Jason A.;Drevets, Wayne C.;Moseman, Scott E.;Bodurka, Jerzy;Barcalow, Joel C.;Simmons, W. Kyle
通讯作者：
Simmons, W. Kyle