CXCL12/CXCR4 promotes motility and proliferation of glioma cells
CXCL12/CXCR4 promotes motility and proliferation of glioma cells
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DOI：
10.4161/cbt.9.1.10342
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Lopes, Maria C.
中科院分区：
文献类型：
--
作者：
do Carmo, Analia;Patricio, Ines;Lopes, Maria C.
胶质母细胞瘤（GBM）是最具侵袭性的恶性脑肿瘤。最近的研究表明，胶质瘤样本的特征是CXCR4， CXCL12/sDF-1趋化因子受体的表达增加。为了更好地了解CXCR4在GBM生物学中的作用，我们进行了一项综合研究，同时评估了CXCR4/CXCL12信号通路对人类GBM细胞系增殖、存活和运动的贡献。我们的结果表明，CXCR4/CXCL12轴诱导细胞增殖和细胞运动性增加。阻断CXCR4可显著增加细胞凋亡。综上所述，我们的研究结果表明CXCR4/CXCL12信号通路可能参与GBM的发展，并强调了该通路在GBM患者中的治疗潜力。
Glioblastoma (GBM) is the most aggressive and malignant brain tumor. Recent studies indicated that glioma samples are characterized by increased expression of CXCR4, the CXCL12/sDF-1 chemokine receptor. To better understand the role of CXCR4 in GBM biology we performed an integrated study where we simultaneously evaluate the contribution of the CXCR4/CXCL12 signaling pathway to the proliferation, survival and motility of a human GBM cell line. Our results indicated that CXCR4/CXCL12 axis induced an increase in cell proliferation and in cell motility. The blockage of CXCR4 induced a significant increase of apoptosis. Together, our results indicated that CXCR4/CXCL12 signalling pathway may contribute to GBM development and emphasize the therapeutic potential of this pathway in patients with GBM.