Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms.
Therapeutic potential of aromatic plant extracts in Alzheimer's disease: Comprehensive review of their underlying mechanisms.
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DOI：
10.1111/cns.14234
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发表时间：
2023-08
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
本综述旨在概述芳香植物提取物在阿尔茨海默病(AD)中的应用及其作用机制研究的最新进展，以证明其在阿尔茨海默病(AD)治疗中的价值。AD是一种神经退行性疾病，其发病机制复杂，以严重的认知功能障碍为特征。目前，治疗AD的药物很少，治疗主要集中在缓解症状上。芳香疗法是一种传统的补充替代疗法，侧重于通过吸入或透皮给药芳香植物提取物来预防和治疗疾病。近年来，使用芳香植物提取物治疗阿尔茨海默病的研究越来越多，并显示出明确的治疗效果。我们系统地总结了2000-2022年间PubMed、Science Direct、Google Scholar和中国国家知识基础设施收录的关于芳香植物提取物在阿尔茨海默病治疗中的潜在应用的体外、体内和临床研究。我们的文献调查表明，芳香植物提取物通过抗淀粉样蛋白、抗tau磷酸化、抗胆碱酯酶、抗炎和抗氧化应激机制来调节病理变化，从而发挥抗AD作用(图1)。该综述为芳香植物提取物抗AD新药的研究提供了新的策略。芳香植物提取物治疗阿尔茨海默病的潜在机制。
The aim of this review is to outline recent advancements in the application and mechanistic studies of aromatic plant extracts in Alzhermer`s disease (AD) to demonstrate their value in the management of this disease. AD is a neurodegenerative disease with a complex pathogenesis characterized by severe cognitive impairment. Currently, there are very few drugs available for the treatment of AD, and treatments are primarily focused on symptom relief. Aromatherapy is a traditional complementary alternative therapy that focuses on the prevention and treatment of the disease through the inhalation or transdermal administration of aromatic plant extracts. Over the past few years, studies on the use of aromatic plant extracts for the treatment of AD have been increasing and have demonstrated a definitive therapeutic effect. We systematically summarized in vitro, in vivo, and clinical studies focusing on the potential use of aromatic plant extracts in the treatment of AD in PubMed, ScienceDirect, Google Scholar, and the Chinese National Knowledge Infrastructure from 2000 to 2022. Our literature survey indicates that aromatic plant extracts exert anti‐AD effects by modulating pathological changes through anti‐amyloid, anti‐tau phosphorylation, anti‐cholinesterase, anti‐inflammation, and anti‐oxidative stress mechanisms (Figure 1). This review provides a future strategy for the research of novel anti‐AD drugs from aromatic plant extracts. Potential mechanisms of aromatic plant extracts for the treatment of Alzheimer's disease.
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1002/trc2.12050
发表时间：
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影响因子：
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作者：
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通讯作者：
Zhong, Kate