Regulation and biological function of the liver-specific miR-122
Regulation and biological function of the liver-specific miR-122
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DOI：
10.1042/bst0381553
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发表时间：
2010-12-01
影响因子：
3.9
通讯作者：
Jopling, Catherine L.
中科院分区：
文献类型：
--
作者：
Lewis, Andrew P.;Jopling, Catherine L.
miRNAs (microRNAs) are important regulators of gene expression In higher eukaryotes the tightly controlled expression of different miRNAs each of which regulates multiple target mRNAs is crucial for the maintenance of tissue type and the control of differentiation miR 122 is a highly lover specific miRNA that is important in hepatitis C virus infection cholesterol metabolism and hepatocellular carcinoma In the present review we discuss the effects of miR 122 on liver physiology and pathology Recent evidence of pathways involved in the regulation of miR 122 expression is also considered
