Investigating the influence of environmental factors on the incidence of renal disease with compositional data analysis using balances
Investigating the influence of environmental factors on the incidence of renal disease with compositional data analysis using balances
复制标题
使用天平进行成分数据分析来研究环境因素对肾脏疾病发病率的影响
DOI：
10.1016/j.acags.2020.100024
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发表时间：
2020
影响因子：
3.4
通讯作者：
V. Pawlowsky
中科院分区：
文献类型：
--
作者：
J. McKinley;U. Mueller;P. Atkinson;U. Ofterdinger;Chloe Jackson;Siobhan F. Cox;R. Doherty;D. Fogarty;J. Egozcue;V. Pawlowsky
本研究利用一个城市土壤元素浓度的地球化学数据库来研究不确定病因的慢性肾脏疾病（CKD）的标准化发病率（SIRs）与pte对土壤的累积低水平地质和扩散人为污染之间的潜在关系。采用成分数据分析方法确定了与CKDu关联最大的地球化学数据的元素平衡。研究得出结论，人为因素和地质因素都可能是造成CKDu高发病率的原因，在一些超级产出地区（SOAs）， CKDu的发病率比平均人群高12倍。As、Cr、Cu、Pb、Sb和Mo的作用突出，可能与历史工业源、大气污染沉积和制动排放等人为来源有关。地质因素在天然存在的潜在有毒元素（pte）相对浓度升高的地区显示出重要作用。
This research uses an urban soil geochemistry database of elemental concentration to examine the potential relationship between Standardised Incidence Rates (SIRs) of Chronic Kidney Disease (CKD) of uncertain aetiology (CKDu), and cumulative low level geogenic and diffuse anthropogenic contamination of soils with PTEs. A compositional data analysis approach was applied to determine the elemental balance(s) of the geochemical data showing the greatest association with CKDu. The research concludes that both anthropogenic and geogenic factors may be contributing influences to explain high incidences of CKDu, up to 12 times greater in some Super Output Areas (SOAs) than would be expected for the average population. The role of As, Cr, Cu, Pb, Sb and Mo was highlighted, which may be linked to anthropogenic sources such as historical industrial sources, atmospheric pollution deposition and brake emissions. Geogenic factors were shown to be important in areas with elevated relative concentrations of naturally occurring potentially toxic elements (PTEs).