Functional MRI BOLD signal coincides with electrical activity in the rat whisker barrels.
Functional MRI BOLD signal coincides with electrical activity in the rat whisker barrels.
复制标题
功能性 MRI BOLD 信号与大鼠胡须桶中的电活动一致。
DOI：
10.1002/mrm.1910380604
复制
发表时间：
1997
影响因子：
3.3
通讯作者：
Shulman,RG
中科院分区：
文献类型：
--
作者：
Yang,X;Hyder,F;Shulman,RG
功能性MRI（fMRI）提供了一种基于血氧水平依赖（BOLD）图像对比度（主要是由于局部灌注增加）的非侵入性方法来绘制脑功能活动。最近，Malonek和Grinvald（Science 272：551-554，1996）提出，在持续的功能激活期间，灌注的增加比局部电活动分布在更大的区域上。在这项研究中，它表明，在持续刺激大鼠胡须的BOLD功能磁共振成像信号的空间分布具有相同的空间模式和尺寸的神经元电活动在大鼠胡须桶。
Functional MRI (fMRI) provides a noninvasive method for mapping brain functional activity based on blood oxygenation level dependent (BOLD) image contrast that is primarily due to localized increases in perfusion. Recently, Malonek and Grinvald (Science272:551–554, 1996) suggested that during sustained functional activation, the increases in perfusion were spread over a much larger area than the localized electrical activity. In this study, it is demonstrated that the spatial distribution of the BOLD fMRI signal during sustained stimulation of rat whiskers has the same spatial pattern and dimension as that of neuronal electrical activity in the rat whisker barrels.