Association of weight gain in infancy and early childhood with metabolic risk in young adults
Association of weight gain in infancy and early childhood with metabolic risk in young adults
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DOI：
10.1210/jc.2006-1071
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发表时间：
2007-01-01
影响因子：
5.8
通讯作者：
Rossner, Stephan
中科院分区：
文献类型：
--
作者：
Ekelund, Ulf;Ong, Ken K.;Rossner, Stephan
内容：早期产后生活已被建议作为一个重要的窗口，在此期间，长期健康的风险可能会受到影响。目的：本研究的目的是研究在婴儿期（0-6个月）和幼儿期（3-6岁）的代谢综合征的组成部分在年轻adult.Design：这是一个前瞻性队列研究（斯德哥尔摩体重发展研究）之间的独立关联。设定：这项研究是在一个普通community.Participants：受试者包括128（54名男性）单例，从出生到17岁。主要结果测量：这些年轻人都不符合代谢综合征的全部标准。因此，我们计算了一个连续的聚集代谢风险评分，通过平均以下组成部分的标准化值：腰围，血压，空腹甘油三酯，高密度脂蛋白胆固醇，葡萄糖和胰岛素水平。（标准化β = 0.16; P < 0.0001），但在儿童早期（标准化β = 0.10; P = 0.23），校正了出生体重，胎龄，目前的身高，母亲的脂肪量和17岁时的社会经济地位。进一步调整目前的脂肪量和体重增加在儿童时期并没有改变婴儿期体重增加与代谢风险评分之间的显着关联（标准化β = 0.20; P = 0.007）。结论：快速体重增加在婴儿期（0-6个月），但不是在儿童早期（3-6年）预测聚集的代谢风险在17岁。即使在很小的年龄，对适度快速体重增加的早期干预也可能有助于降低成人心血管疾病的风险。
Context: Early postnatal life has been suggested as an important window during which risks for long-term health may be influenced.Objective: The aim of this study was to examine the independent associations between weight gain during infancy (0-6 months) and early childhood (3-6 yr) with components of the metabolic syndrome in young adults.Design: This was a prospective cohort study (The Stockholm Weight Development Study). Setting: The study was conducted in a general community.Participants: Subjects included 128 (54 males) singletons, followed from birth to 17 yr.Main Outcome Measure: None of these young adults met the full criteria for the metabolic syndrome. We therefore calculated a continuous clustered metabolic risk score by averaging the standardized values of the following components: waist circumference, blood pressure, fasting triglycerides, high-density lipoprotein cholesterol, glucose, and insulin level.Results: Clustered metabolic risk at age 17 yr was predicted by weight gain during infancy (standardized beta = 0.16; P < 0.0001) but not during early childhood (standardized beta = 0.10; P = 0.23), adjusted for birth weight, gestational age, current height, maternal fat mass, and socioeconomic status at age 17 yr. Further adjustment for current fat mass and weight gain during childhood did not alter the significant association between infancy weight gain with the metabolic risk score (standardized beta = 0.20; P = 0.007).Conclusions: Rapid weight gain during infancy (0-6 months) but not during early childhood (3-6 yr) predicted clustered metabolic risk at age 17 yr. Early interventions to moderate rapid weight gain even at very young ages may help to reduce adult cardiovascular disease risks.