Ethnic differences in bone geometry and strength are apparent in childhood.
Ethnic differences in bone geometry and strength are apparent in childhood.
复制标题
骨骼几何形状和强度的种族差异在童年时期就很明显。
DOI：
10.1016/j.bone.2009.01.006
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发表时间：
2009
期刊：
影响因子：
4.1
通讯作者：
Petit,MA
中科院分区：
文献类型：
--
作者：
Wetzsteon,RJ;Hughes,JM;Kaufman,BC;Vazquez,G;Stoffregen,TA;Stovitz,SD;Petit,MA
PURPOSEEthnic differences in bone strength and structure likely contribute to the disparity in fracture rates, however few studies have assessed bone structure in multiethnic cohorts of children. The purpose of this study was to investigate ethnic differences in bone strength in childhood and to characterize the structural bases for these differences.METHODSPeripheral quantitative computed tomography (pQCT 3000, Orthometrix) was used to assess bone parameters at the radius and tibia in Caucasian (CA, n=21), African American (AA, n=23), and Hispanic (HI, n=29) children (10.9±0.1 yrs). At the distal site (8%), we measured compressive bone strength (BSI), trabecular and total bone density, and total bone area. Polar strength-strain index, total and cortical bone area, and cortical density were assessed at the midshaft (50%). Muscle cross-sectional area (CSA) and fat CSA were measured at the tibia (66%) and the radius (50%). Physical activity and calcium intake were assessed by questionnaire. Analysis of covariance was used to compare bone outcomes among ethnic groups adjusting for age, sex, limb length and muscle CSA.RESULTSAge, BMI, and body composition were similar among the 3 groups, however AA children were taller and had longer bone length. At all sites, AA and HI children had higher bone strength (SSIp and BSI +10–37%) than CA children due mainly to greater bone tissue density (2–18%>CA) at the distal sites of the radius and tibia. The greater bone strength at the midshaft was due to both a higher bone density (2–5%) and greater bone area than CA (7–18%).CONCLUSIONAA and HI children have significantly higher bone strength than CA children, due to greater bone volumetric density and greater cortical area. AA and HI children also have higher bone strength relative to load. These observations suggest that ethnic differences in bone strength manifest in childhood.
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DOI：
10.1093/ajcn/60.6.837
发表时间：
1994-12
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
A. Prentice;T. Parsons;T. Cole
通讯作者：
A. Prentice;T. Parsons;T. Cole
生长的两个方面：骨骼完整性的益处和风险
影响因子：
4
作者：
A. Parfitt
通讯作者：
A. Parfitt
低收入黑人儿童骨骼发育先进。
影响因子：
3.3
作者：
S. Garn;S. Garn;S. T. Sandusky;S. T. Sandusky;J. Nagy;J. Nagy;M. Mccann;M. Mccann
通讯作者：
M. Mccann
老龄化白人和非洲人群的骨密度
DOI：
--
发表时间：
1979
期刊：
The Lancet
影响因子：
--
作者：
L. Solomon
通讯作者：
L. Solomon
DOI：
10.1210/jcem.83.5.4765
发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Gilsanz,V;Skaggs,DL;Kovanlikaya,A;Sayre,J;Loro,ML;Kaufman,F;Korenman,SG
通讯作者：
Korenman,SG