Oral contraceptives: side effects and depression in adolescent girls
Oral contraceptives: side effects and depression in adolescent girls
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DOI：
10.1016/j.contraception.2006.09.008
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发表时间：
2007-04-01
期刊：
影响因子：
2.9
通讯作者：
Kerns, Jermifer
中科院分区：
文献类型：
--
作者：
O'Connell, Katharine;Davis, Anne R.;Kerns, Jermifer
目的：这项研究进行，以确定的副作用，包括抑郁症，口服避孕药（OCs）在青春期girls.Methods：我们进行了一项随机试验，OCs痛经，评估副作用和抑郁症。76名青少年接受了OC（20 μ g炔雌醇/100 mg左炔诺孕酮）或安慰剂的双盲方式3个月。我们使用开放式和封闭式问题格式确定OC副作用。参与者自我管理的流行病学研究中心抑郁量表（CES-D），以评估抑郁症状。结果：五十七名参与者（77%）报告至少有一个副作用（中位数=2，范围=0-8，四分位数间距=1.0-3.25）。OC组和安慰剂组报告的副作用的数量和类型相似。两组之间的平均退出CES-D评分相当[OC组，14.0（SD=9.2）;安慰剂组，14.4（SD=8.1）; p= 0.86]。结论：用OC或安慰剂治疗的青少年经历了相似数量和类型的OC副作用，以及抑郁症状。(c)2007年爱思唯尔公司All rights reserved.
Objective: The study was undertaken to determine the side effects, including depression, of oral contraceptives (OCs) in adolescent girls.Methods: We conducted a randomized trial of OCs for dysmenorrhea, which assessed side effects and depression. Seventy-six adolescents received an OC (20 mu g of ethinyl estradiol/100 mg of levonorgestrel) or a placebo in a double-blind fashion for 3 months. We ascertained OC side effects using open-ended and closed question formats. Participants self-administered the Center for Epidemiologic Studies Depression Scale (CES-D) to assess depressive symptoms.Results: Fifty-seven participants (77%) reported at least one side effect (median=2, range=0-8, interquartile range=1.0-3.25). The number and the type of side effects reported in the OC group and in the placebo group were similar. Mean exit CES-D scores were comparable between groups [OC group, 14.0 (SD=9.2); placebo group, 14.4 (SD=8.1); p=.86].Conclusion: Adolescents treated with an OC or a placebo experienced similar numbers and types of OC side effects, as well as depressive symptoms. (c) 2007 Elsevier Inc. All rights reserved.