Dynamics of cooperativity in chemical sensing among cell-surface receptors.
Dynamics of cooperativity in chemical sensing among cell-surface receptors.
复制标题
细胞表面受体之间化学传感的协同动力学。
DOI：
10.1103/physrevlett.107.178101
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发表时间：
2011
影响因子：
8.6
通讯作者：
Wingreen,NedS
中科院分区：
文献类型：
--
作者：
Skoge,Monica;Meir,Yigal;Wingreen,NedS
感觉受体之间的协同作用为提高信号转导的敏感性提供了一种普遍的机制。特别是，细菌趋化性受体协同作用，产生对化学效应剂浓度极其敏感的反应。然而，在大分子复合体中，受体之间的协作性必然基于局部相互作用，因此从根本上与受体构象动力学的减慢有关，这增加了固有噪声。因此，目前还不清楚协作性是否或在什么条件下实际上提高了浓度测量的精度。我们使用一个简单的受体-受体相互作用的伊辛型模型显式地计算了感知浓度变化的信噪比(SNR)，该模型通过标度变量推广，发现最佳的信噪比总是由独立的受体实现的。
Cooperative interactions among sensory receptors provide a general mechanism to increase the sensitivity of signal transduction. In particular, bacterial chemotaxis receptors interact cooperatively to produce <?format ?>an ultrasensitive response to chemoeffector concentrations. However, cooperativity between receptors in large macromolecular complexes is necessarily based on local interactions and consequently is fundamentally connected to slowing of receptor-conformational dynamics, which increases intrinsic noise. Therefore, <?format ?>it is not clear whether or under what conditions cooperativity actually increases the precision of the concentration measurement. We explicitly calculate the signal-to-noise ratio (SNR) for sensing a concentration change using a simple, Ising-type model of receptor-receptor interactions, generalized via scaling arguments, and find that the optimal SNR is always achieved by independent receptors.