Gold nanostructures as a platform for combinational therapy in future cancer therapeutics.
Gold nanostructures as a platform for combinational therapy in future cancer therapeutics.
复制标题
DOI：
10.3390/cancers3011081
复制
发表时间：
2011-03-04
期刊：
影响因子：
5.2
通讯作者：
Chithrani DB
中科院分区：
文献类型：
--
作者：
Jelveh S;Chithrani DB
纳米技术领域目前在许多方面正在经历爆炸性的发展。预计这项技术将产生创新，并在癌症治疗中发挥关键作用。在其他纳米粒子(NP)系统中，球形金纳米粒子(GNPs)、金纳米棒(GNRs)、金纳米壳(GNSS)和金纳米笼(GNCs)在癌症治疗中的应用取得了巨大进展。在治疗癌症方面，放射治疗和化疗仍然是最广泛使用的治疗方案，癌症研究的最新进展表明，在这些方案中加入金纳米结构增强了对肿瘤细胞的杀伤力。这些纳米结构进一步提供了更好的载药、靶向和控制药物释放的策略，以最大限度地减少化疗和光动力治疗中使用的高毒性抗癌药物的副作用。此外，金纳米结构在暴露于紫外线或近红外光时的生热能力正被用于光热治疗中的局部肿瘤细胞损伤。因此，金纳米结构提供了一个多功能的平台，可以集成许多治疗方案，从而在抗击癌症的斗争中实现有效的联合疗法。在这篇综述文章中，将讨论以金为基础的纳米粒子朝着更好的治疗方向发展的最新进展。基于金纳米结构的多功能平台，具有靶向配体、治疗分子和成像造影剂，为癌症研究提供了一系列有前途的方向。
The field of nanotechnology is currently undergoing explosive development on many fronts. The technology is expected to generate innovations and play a critical role in cancer therapeutics. Among other nanoparticle (NP) systems, there has been tremendous progress made in the use of spherical gold NPs (GNPs), gold nanorods (GNRs), gold nanoshells (GNSs) and gold nanocages (GNCs) in cancer therapeutics. In treating cancer, radiation therapy and chemotherapy remain the most widely used treatment options and recent developments in cancer research show that the incorporation of gold nanostructures into these protocols has enhanced tumor cell killing. These nanostructures further provide strategies for better loading, targeting, and controlling the release of drugs to minimize the side effects of highly toxic anticancer drugs used in chemotherapy and photodynamic therapy. In addition, the heat generation capability of gold nanostructures upon exposure to UV or near infrared light is being used to damage tumor cells locally in photothermal therapy. Hence, gold nanostructures provide a versatile platform to integrate many therapeutic options leading to effective combinational therapy in the fight against cancer. In this review article, the recent progress in the development of gold-based NPs towards improved therapeutics will be discussed. A multifunctional platform based on gold nanostructures with targeting ligands, therapeutic molecules, and imaging contrast agents, holds an array of promising directions for cancer research.