Harnessing evolutionary biology to combat infectious disease.
Harnessing evolutionary biology to combat infectious disease.
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病原体表现出藐视治疗干预的非凡能力。这种结果是由进化驱动的，要么是对干预的直接反应（例如抗生素耐药性的进化），要么是通过长期的共同进化产生的宿主或寄生虫特征，这些特征以不希望的或不可预测的方式与治疗相互作用。为了取得进展，进化生物学的概念和技术必须与传统的免疫学和病原体生物学方法深度融合。跨学科的方法可以为控制策略甚至患者治疗提供信息，使我们能够应对控制传染病的当前和未来挑战。
Pathogens exhibit remarkable abilities to flout therapeutic intervention. This outcome is driven by evolution, either as a direct response to intervention (e.g. the evolution of antibiotic resistance), or through long-term coevolution generating host or parasite traits that interact with therapy in undesirable or unpredicted ways. To make progress, the concepts and techniques of evolutionary biology must be deeply integrated with traditional approaches to immunology and pathogen biology. An interdisciplinary approach can inform control strategies, or even patient treatment, positioning us to meet the current and future challenges of controlling infectious diseases.