Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients
Platelet-to-lymphocyte ratio better predicts inflammation than neutrophil-to-lymphocyte ratio in end-stage renal disease patients
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DOI：
10.1111/hdi.12040
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发表时间：
2013-07-01
影响因子：
1.3
通讯作者：
Tonbul, H. Zeki
中科院分区：
文献类型：
--
作者：
Turkmen, Kultigin;Erdur, Fatih Mehmet;Tonbul, H. Zeki
中性粒细胞与淋巴细胞比率（NLR）被引入作为确定终末期肾病（ESRD）患者炎症的潜在标志物。近年来，研究发现，在心脏病和非心脏病患者中，血小板与淋巴细胞比率（PLR）和NLR与炎症标志物包括肿瘤坏死因子（TNF-α）和白细胞介素（IL）-6呈正相关。血液透析（HD）和腹膜透析（PD）患者中缺乏关于PLR及其与炎症相关性的数据。因此，我们的目的是确定PLR，NLR和炎症之间的关系，在ESRD患者。这是一项横断面研究，涉及62例ESRD患者（29例女性，33例男性;平均年龄49.6 ± 14.6岁），在Necmettin Erbakan University透析室接受PD或HD治疗6个月。检测PLR、NLR、C反应蛋白、TNF-α、IL-6水平。与HD患者相比，PD患者的PLR、NLR、血清超敏C反应蛋白、IL-6和TNF-α水平显著升高。与PLR患者相比，PLR 140的ESRD患者的NLR、IL-6和TNF-α水平显著更高
Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential marker to determine inflammation in end-stage renal disease (ESRD) patients. Recently, platelet-to-lymphocyte ratio (PLR) and NLR were found to positively correlated with inflammatory markers including tumor necrosis factor- (TNF-) and interleukin (IL)-6 in cardiac and noncardiac patients. Data regarding PLR and its association with inflammation are lacking in hemodialysis (HD) and peritoneal dialysis (PD) patients. Hence, we aimed to determine the relationship between PLR, NLR, and inflammation in ESRD patients. This was a cross-sectional study involving 62 ESRD patients (29 females, 33 males; mean age, 49.6 +/- 14.6 years) receiving PD or HD for 6 months in the Dialysis Unit of Necmettin Erbakan University. PLR, NLR, C-reactive protein, TNF-, IL-6 levels were measured. PLR, NLR, serum high sensitive C-reactive protein, IL-6, and TNF- levels were significantly higher in PD patients when compared with HD patients. ESRD patients with PLR140 had significantly higher NLR, IL-6, and TNF- levels when compared to patients with PLR