Brain Health in Children with Type 1 Diabetes: Risk and Protective Factors.

Brain Health in Children with Type 1 Diabetes: Risk and Protective Factors.
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1型糖尿病儿童的大脑健康:风险和保护因素。

DOI:
10.1007/s11892-021-01380-w
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发表时间:
2021-03-14
影响因子:
4.2
通讯作者:
Jordan LC
Jordan LC
中科院分区:
医学2区
文献类型:
--
作者:
Jaser SS;Jordan LC

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综合1型糖尿病(T1D)儿童神经认知并发症的研究结果,并强调潜在的风险和保护因素。新出现的证据表明,高血糖和时间范围可能是更重要的大脑发育比低血糖发作。此外,T1D诊断时的糖尿病酮症酸中毒(DKA)似乎是神经认知并发症的一个特定风险因素,特别是执行功能技能和记忆缺陷,通过先进的磁共振成像方法观察到大脑白色微结构的差异,在诊断为DKA的儿童中观察到注意力和记忆力指标评分较低。其他可能影响神经认知发育的因素包括儿童睡眠、看护者痛苦和糖尿病设备使用,可能是由于血糖控制改善。我们强调了T1D儿童的神经认知风险和保护因素,以及未来在这一高危人群中进行研究的优先事项。
To synthesize findings from studies of neurocognitive complications in children with type 1 diabetes (T1D) and highlight potential risk and protective factors. Emerging evidence suggests that hyperglycemia and time in range may be more important for brain development than episodes of hypoglycemia. Further, diabetic ketoacidosis (DKA) at the time of T1D diagnosis appears to be a particular risk factor for neurocognitive complications, particularly deficits in executive function skills and memory, with differences in cerebral white matter microstructure seen via advanced magnetic resonance imaging methods, and lower scores on measures of attention and memory observed among children who were diagnosed in DKA. Other factors that may influence neurocognitive development include child sleep, caregiver distress, and diabetes device use, presumably due to improved glycemic control. We highlight neurocognitive risk and protective factors for children with T1D and priorities for future research in this high-risk population.
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