tRNase Z
tRNase Z
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DOI：
10.2174/092986607779816050
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发表时间：
2007-01-01
影响因子：
1.6
通讯作者：
Vioque, Agustin
中科院分区：
文献类型：
--
作者：
Ceballos, Maria;Vioque, Agustin
内切核酸酶tRNase Z通过特异性内切核酸裂解催化tRNA前体的成熟3'末端的产生。该酶的特点是从代表所有领域的生命以及从细胞器的生物体，并已确定三种细菌酶的晶体结构。本文综述了它的性质和它的结构，底物识别，切割位点的定义，以及潜在的实际应用。
Endonuclease tRNase Z catalyzes the generation of the mature 3' end of tRNA precursors through specific endonucleolytic cleavage. The enzyme has been characterized from organisms representative of all domains of life as well as from organelles, and the crystal structure of three bacterial enzymes has been determined. This review presents an overview of its properties and what is known about its structure, substrate recognition, cleavage site definition, and potential practical applications.