1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana.
1,135 Genomes Reveal the Global Pattern of Polymorphism in Arabidopsis thaliana.
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DOI：
10.1016/j.cell.2016.05.063
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发表时间：
2016-07-14
期刊：
影响因子：
64.5
通讯作者：
1001 Genomes Consortium
中科院分区：
文献类型：
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作者：
1001 Genomes Consortium. Electronic address: magnus.nordborg@gmi.oeaw.ac.at;1001 Genomes Consortium
拟南芥是研究基本生理、细胞和分子过程的模式生物。它也极大地推进了我们对种内基因组变异的理解。我们提出了一个详细的变化图，在1,135高质量的重新测序的自然近交系代表本土欧亚和北非的范围，最近殖民北美。我们确定的残遗种群，继续居住在祖先的栖息地，主要是在伊比利亚半岛。它们与一个从一个未知的冰川避难所传播到北方纬度的血统混合在一起，现在在更广泛的栖息地中被发现。深入了解物种的历史和遗传多样性的精细分布，为通过基因组和表观基因组与分子和非分子表型的整合充分利用拟南芥自然变异提供了基础。展示了1,135个拟南芥自然近交系的基因组发现了继续栖息在祖先栖息地的残遗种群末次冰期最大期在构建残遗种群分布方面很重要该集合将在物种范围内连接基因型和表型对1,000多个拟南芥自然近交系的基因组测序分析揭示了其全球种群结构，迁移模式和进化历史，并为研究表型变异和适应提供了丰富的遗传资源。
Arabidopsis thaliana serves as a model organism for the study of fundamental physiological, cellular, and molecular processes. It has also greatly advanced our understanding of intraspecific genome variation. We present a detailed map of variation in 1,135 high-quality re-sequenced natural inbred lines representing the native Eurasian and North African range and recently colonized North America. We identify relict populations that continue to inhabit ancestral habitats, primarily in the Iberian Peninsula. They have mixed with a lineage that has spread to northern latitudes from an unknown glacial refugium and is now found in a much broader spectrum of habitats. Insights into the history of the species and the fine-scale distribution of genetic diversity provide the basis for full exploitation of A. thaliana natural variation through integration of genomes and epigenomes with molecular and non-molecular phenotypes. The genomes of 1,135 naturally inbred lines of Arabidopsis thaliana are presented Relict populations that continue to inhabit ancestral habitats were discovered The last glacial maximum was important in structuring the distribution of relicts This collection will connect genotypes and phenotypes on a species-wide level Genomic sequencing analysis of over 1,000 natural inbred lines of Arabidopsis thaliana reveals its global population structure, migration patterns, and evolutionary history and provides a rich genetic resource for studying phenotypic variation and adaptation.