The acute phase response of plasma protein synthesis during experimental inflammation.
The acute phase response of plasma protein synthesis during experimental inflammation.
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DOI：
10.1016/s0021-9258(18)34015-8
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发表时间：
1982-09
期刊：
影响因子：
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通讯作者：
G. Schreiber;G. Howlett;M. Nagashima;A. Millership;H. Martin;J. Urban;L. Kotler
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文献类型：
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作者：
G. Schreiber;G. Howlett;M. Nagashima;A. Millership;H. Martin;J. Urban;L. Kotler
结果炎症反应急性期大鼠血浆蛋白浓度——测定炎症诱导后不同时间血浆或血清中各种蛋白的浓度。结果如图1所示。转铁蛋白的浓度变化最小。健康动物血浆中其含量为3.5 ~ 4.5 g/l，注射松节油后48 h仍保持在该范围内。相比之下，az-macroglobulin（未包括在图中）的浓度从0.014 g/l增加到4.5 g/l，即320倍。48 h后a -酸性糖蛋白浓度由0.17降至3.2 g/l，急性期主要at-蛋白浓度由0.46降至7.0 g/l，诱导炎症2 d后血清白蛋白水平由35降至23 g/l。血浆蛋白浓度的最大变化发生在红细胞沉降速率从健康大鼠的2 mm/h增加到20 mm/h的最大值的同时。血液中白细胞数量的增加仅在4天后开始，并在6天后未达到最大值。急性期反应期间~-[l- ' ~ C]亮氨酸进入血浆蛋白的掺入率-在图2中，放射性亮氨酸的掺入率与诱导炎症后的时间有关。在炎症,
RESULTSConcentrations of Proteins in Plasma in Rats during the Acute Phase Response toInflammation-The concentrations of various proteins in plasma or serum were measured at different times after inducing inflammation. The results are shown in Fig. 1. The smallest changes in concentration were found for transferrin. Its level in plasma ranged from 3.5 to 4.5 g/liter in healthy animals and remained in that range 48 h after injection of turpentine. In contrast, the concentration of az-macroglobulin (not included in the figure) increased from 0.014 to 4.5 g/liter, ie 320-fold. The concentration of a,-acid glycoprotein changed from 0.17 to 3.2 g/liter, and that of major acute phase at-protein changed from 0.46 to 7.0 g/liter after 48 h. The serum level of albumin decreased from 35 to 23 g/liter 2 days after inducing inflammation. The maximum of the changes in concentration of plasma proteins occurred at about the same time at which the rate of sedimentation of erythrocytes increased to a maximum value of 20 mm/h compared with 2 mm/h in healthy rats. An increase in the number of leucocytes in the bloodstream started only after 4 days and had not reached its maximum after 6 days. Rates of Incorporation of~-[l-‘~ C] Leucine into Plasma Proteins during the Acute Phase Response-In Fig. 2 the rate of incorporation of radioactive leucine is plotted against the time after inducing inflammation. During inflammation,