Life's Simple 7 and risk of incident stroke: the reasons for geographic and racial differences in stroke study.
Life's Simple 7 and risk of incident stroke: the reasons for geographic and racial differences in stroke study.
复制标题
DOI：
10.1161/strokeaha.111.000352
复制
发表时间：
2013-07
期刊：
影响因子：
8.3
通讯作者：
Cushman M
中科院分区：
文献类型：
--
作者：
Kulshreshtha A;Vaccarino V;Judd SE;Howard VJ;McClellan WM;Muntner P;Hong Y;Safford MM;Goyal A;Cushman M
美国心脏协会开发了 Life's Simple 7 (LS7) 作为定义心血管健康的指标。我们调查了 LS7 与美国黑人和白人中风之间的关联。 REGARDS 是一个基于全国人口的队列，包括 30,239 名年龄≥45 岁的黑人和白人，从 2003 年至 2007 年的美国人口中抽样。数据通过电话、自填问卷和家庭检查收集。中风事件是通过每年两次的参与者接触以及医疗记录的裁决来确定的。 LS7 组成部分（血压、胆固醇、血糖、体重指数、吸烟、体力活动和饮食）的水平分别编码为不良（0 分）、中等（1 分）或理想（2 分）健康状况。 LS7 总体评分分为心血管健康状况不佳（0-4）、平均（5-9）或最佳（10-14）。在 22,914 名拥有 LS7 数据且既往没有心血管疾病的受试者中，在 4.9 年的随访中，有 432 例发生中风。在调整人口统计、社会经济地位和居住地区后，LS7 评分的每个更好的健康类别都与降低 25% 的中风风险相关（HR=0.75，95% CI = 0.63，0.90）。黑人和白人之间的关联相似（交互作用 p 值 = 0.55）。 LS7 评分高 1 分与中风风险降低 8% 相关（HR=0.92，95% CI=0.88，0.95）。根据 LS7 评分，在黑人和白人中，更好的心血管健康状况与较低的中风风险相关，而分数的微小差异是重要的中风决定因素。
The American Heart Association developed Life’s Simple 7 (LS7) as a metric defining cardiovascular health. We investigated the association between LS7 and incident stroke in black and white Americans. REGARDS is a national population-based cohort of 30,239 blacks and whites, aged ≥45 years, sampled from the US population in 2003 – 2007. Data were collected by telephone, self-administered questionnaires and an in-home exam. Incident strokes were identified through bi-annual participant contact followed by adjudication of medical records. Levels of the LS7 components (blood pressure, cholesterol, glucose, body mass index, smoking, physical activity, and diet) were each coded as poor (0 point), intermediate (1 point) or ideal (2 points) health. An overall LS7 score was categorized as inadequate (0–4), average (5–9) or optimum (10–14) cardiovascular health. Among 22,914 subjects with LS7 data and no previous cardiovascular disease, there were 432 incident strokes over 4.9 years of follow-up. After adjusting for demographics, socioeconomic status, and region of residence, each better health category of the LS7 score was associated with a 25% lower risk of stroke (HR=0.75, 95% CI = 0.63, 0.90). The association was similar for blacks and whites (interaction p-value = 0.55). A one point higher LS7 score was associated with an 8% lower risk of stroke (HR=0.92, 95% CI=0.88, 0.95). In both blacks and whites better cardiovascular health, based on the LS7 score, is associated with lower risk of stroke, and a small difference in scores was an important stroke determinant.