Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sample
Indicators of anxiety and depression in women with the fragile X premutation: assessment of a clinical sample
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DOI：
10.1111/j.1365-2788.2010.01290.x
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发表时间：
2010-07-01
影响因子：
3.6
通讯作者：
McConkie-Rosell, A.
中科院分区：
文献类型：
--
作者：
Lachiewicz, A.;Dawson, D.;McConkie-Rosell, A.
背景目前的研究表明，抑郁和焦虑可能是女性与脆性X（FMR 1）premutation的共同问题。我们让33名有FMR 1前突变的妇女和20名没有FMR 1前突变的妇女完成简明卡罗尔抑郁量表（简明CDS）和多维焦虑问卷（MAQ），并提供有关精神健康药物使用的信息。问卷调查结果进行了比较组间和正常样本。三核苷酸（CGG）重复计数也与检查表findings.ResultsBoth妇女与FMR 1前突变和对照组有较高的当前心理健康药物的使用（33%对35%）。两组中约有1/3的女性的Brief CDS总T评分较高（33% vs. 30%）。与对照组相比，更多的FMR 1前突变女性至少有一个MAQ总分或子量表T评分升高（39% vs. 10%，P = 0.03）。21%的FMR 1前突变女性具有本研究中针对的所有三个痛苦指标，而对照样本中没有女性（P < 0.05）。使用斯皮尔曼等级相关性，CGG重复次数和异常检查表结果之间没有统计学显著相关性，尽管CGG重复次数> 100的女性（57%）的Brief CDS总T评分升高的百分比高于CGG重复次数< 100的女性（16%）（P = 0.02）。更多的妇女与> 100 CGG重复也有所有三个指标的焦虑和抑郁症（P = 0.03）。筛查工具，如简短的CDS和MAQ可能是有用的，以确定这些妇女在诊所设置。积极的识别可能会导致增加精神卫生保健和治疗。
BackgroundCurrent research suggests that depression and anxiety may be common problems in women with the fragile X (FMR1) premutation.MethodsTo learn more about this in a clinical setting, we asked 33 women with the FMR1 premutation and 20 women without the FMR1 premutation to complete the Brief Carroll Depression Scale (Brief CDS) and the Multidimensional Anxiety Questionnaire (MAQ) and to provide information about mental health medication use. Questionnaire findings were compared between groups and with normative samples. Trinucleotide (CGG) repeat counts were also correlated to checklist findings.ResultsBoth women with the FMR1 premutation and the comparison group had high current mental health medication use (33% vs. 35%). Approximately 1/3 of the women from both groups had high Brief CDS Total T-scores (33% vs. 30%). More women with the FMR1 premutation had at least one elevated MAQ Total or sub-scale T-score than the comparison group (39% vs. 10%, P = 0.03). Twenty-one per cent of women with the FMR1 premutation had all three of the indicators of distress targeted in this study vs. none of the women in the comparison samples (P < 0.05). There was no statistically significant correlation between CGG repeat size and abnormal checklist findings using the Spearman rank correlation, although a higher percentage of women with > 100 CGG repeats (57%) had an elevated Brief CDS Total T-score than women with < 100 CGG repeats (16%) (P = 0.02). More women with > 100 CGG repeats also had all three indicators of anxiety and depression (P = 0.03).ConclusionsWomen with the FMR1 premutation appear to have a high incidence of depression and increased symptoms of anxiety. Screening tools like the Brief CDS and the MAQ may be useful to identify these women in the clinic setting. Positive identification could lead to increased mental health care and treatment.