Cardiac transplantation in the rat. I. The effect of histocompatibility differences on graft arteriosclerosis.
Cardiac transplantation in the rat. I. The effect of histocompatibility differences on graft arteriosclerosis.
复制标题
大鼠心脏移植。
DOI：
10.1097/00007890-198903000-00002
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发表时间：
1989
期刊：
影响因子：
6.2
通讯作者：
Makowka,L
中科院分区：
文献类型：
--
作者：
Cramer,DV;Qian,SQ;Harnaha,J;Chapman,FA;Estes,LW;Starzl,TE;Makowka,L
动脉硬化的发展是心脏移植长期存活者最严重和最常见的并发症。我们已经使用了各种近交系大鼠品系与选定的组织相容性差异，以研究长期的，轻度的排斥反应的影响，在长期的心脏移植病理变化的发展。异位心脏同种异体移植物在不同MHC I类（RT 1）的大鼠品系之间交换。A和/或RT 1。E）抗原或MHC相容同源组合中的次要非MHC抗原组。我们的结果表明，在同种异体移植反应轻微且持续时间长的应变组合中，供体心脏表现出病理变化，包括弥漫性间质性心肌纤维化、血管周围纤维化和移植心肌动脉内膜增生。病变不太突出的动物，更多的主动排斥和罕见的菌株，不同的I类组织相容性抗原或同系对照。这些结果表明，在长期人类心脏存活者中观察到的类似病理变化可能反映了低水平、持续的同种异体移植反应，而不是与移植物缺氧或免疫治疗预防移植物排斥反应相关的因素。
The development of arteriosclerosis is the most serious and common complication in long-term survivors of cardiac transplantation. We have used a variety of inbred rat strains with selected histocompatibility differences to examine the influence of prolonged, mild rejection reactions on the development of pathological changes in long-term cardiac allografts. Heterotopic cardiac allografts were exchanged between rat strains that differed for MHC class I (RT 1. A and/or RT1. E) antigens or groups of minor, non-MHC antigens in MHC-compatible congenic combinations. Our results demonstrate that in strain combinations in which the allograft reaction is mild and prolonged, the donor hearts exhibit pathological changes that include a diffuse, interstitial myocardial fibrosis, perivascular fibrosis, and intimal proliferation in arteries of the graft myocardium. The lesions were less prominent in animals with more active rejection and infrequent in strains that differ for class I histocompatibility antigens or syngeneic controls. These results suggest that the comparable pathological changes seen in long-term human cardiac survivors may reflect low-level, persistent allograft reactions rather than factors associated with graft anoxia or effects of immuno-therapy to prevent graft rejection.