Genetic influence on inflammation variables in the elderly
Genetic influence on inflammation variables in the elderly
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DOI：
10.1161/01.atv.0000143856.01669.e7
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发表时间：
2004-11-01
影响因子：
8.7
通讯作者：
Christensen, K
中科院分区：
文献类型：
--
作者：
de Maat, MPM;Bladbjerg, EM;Christensen, K
炎症变量（C反应蛋白[CRP]、纤维蛋白原和可溶性细胞间粘附分子-1 [sICAM-1]）已被确定为心血管疾病的危险因素。目前尚不清楚遗传因素在多大程度上决定了炎症风险因子的调节，本研究的目的是确定这些炎症变量以及急性期调节细胞因子白细胞介素-6（IL-6）和肿瘤坏死因子-α的遗传性方法和结果-CRP、纤维蛋白原、sICAM-1、IL-6、在一项双胞胎研究中测定了TNF-α，该研究包括129对同卵双胞胎和153对异卵同性双胞胎，年龄在73至94岁之间，他们参加了丹麦双胞胎衰老纵向研究。此外，我们确定了选定的遗传多态性对血浆水平变化的影响。遗传因素占炎症变量血浆水平变化的20%至55%。sICAM-1的遗传力最高。我们研究的遗传多态性解释了只有一个小的，微不足道的一部分的遗传率。结论-这项研究在老年双胞胎中提供了证据，在老年人的炎症性心血管危险因素的大量遗传成分。
Background - Inflammation variables (C-reactive protein [CRP], fibrinogen, and soluble intercellular adhesion molecule-1 [sICAM-1]) have been identified as risk factors for cardiovascular disease. It is still not known how much the regulation of inflammatory risk factors is determined by genetic factors, and the aim of this study was to determine the heritability of these inflammation variables and of the acute phase regulating cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at older ages.Methods and Results - The heritability of CRP, fibrinogen, sICAM-1, IL-6, and TNF-alpha was determined in a twin study consisting of 129 monozygotic twin pairs and 153 dizygotic same-sex twins aged 73 to 94 years who participated in the Longitudinal Study of Aging of Danish Twins. Furthermore, we determined the influence of selected genetic polymorphisms on the plasma level variations. Genetic factors accounted for 20% to 55% of the variation in plasma levels of the inflammation variables. The highest heritability was found for sICAM-1. The genetic polymorphisms we studied explained only a small, insignificant part of the heritability.Conclusions - This study in elderly twins provides evidence for a substantial genetic component of inflammatory cardiovascular risk factors among the elderly.