Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse
Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouse
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DOI：
10.1006/bbrc.1998.9882
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发表时间：
1999-01-08
影响因子：
3.1
通讯作者：
Hermans-Borgmeyer, I
中科院分区：
文献类型：
--
作者：
Hermey, G;Methner, A;Hermans-Borgmeyer, I
利用基于PCR的克隆策略，我们从小鼠脑中分离出一个cDNA，并将其命名为fex，因为它编码一种新的推定的G蛋白偶联受体，在卵泡中表达。推导的氨基酸序列显示出较高程度的同源性，糖蛋白受体家族，即FSH，LH和TSH，比其他G蛋白偶联受体。具有18个富含亮氨酸的重复序列的FEX在其N-末端部分中表现出特征，将其表征为在糖蛋白受体家族中独特的。在成年小鼠中，在雄性和雌性性腺、肾上腺髓质和大脑的嗅球中检测到FEX表达。在胚胎发育过程中，fex转录本在各种组织中被瞬时检测到，特别是在中枢神经系统的选定区域、发育中的面部、椎间盘原基和肢芽中。由于fex在活跃的形态发生期间表达，它可能是控制特定胚胎组织生长和分化的信号的重要受体。(C)北京：科学出版社.
Using a PCR-based cloning strategy we have isolated a cDNA from mouse brain and named it fex, because it codes for a novel putative G; protein-coupled receptor expressed in follicles. The deduced amino acid sequence shows a higher degree of homology to the family of glycoprotein receptors, namely those for FSH, LH, and TSH, than to other G; protein-coupled receptors. With 18 leucine-rich repeats FEX exhibits features in its N-terminal portion characterizing it as unique within the glycoprotein receptor family, In the adult mouse fex expression was detected in the male and female gonads, the adrenal medulla, and the olfactory bulb of the brain. During embryonic development fex transcripts were detected transiently in various tissues, particularly in selected regions of the central nervous system, the developing face, the intervertebral discs anlagen, and the limb buds. Because fex was expressed during periods of active morphogenesis, it may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues. (C) 1999 Academic Press.