Interhemispheric Integration: II. Symmetry and Convergence of the Corticostriatal Projections of the Left and the Right Principal Sulcus (PS) and the Left and the Right Supplementary Motor Area (SMA) of the Rhesus Monkey
Interhemispheric Integration: II. Symmetry and Convergence of the Corticostriatal Projections of the Left and the Right Principal Sulcus (PS) and the Left and the Right Supplementary Motor Area (SMA) of the Rhesus Monkey
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DOI：
10.1093/cercor/1.5.408
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发表时间：
1991-09-01
期刊：
影响因子：
3.7
通讯作者：
Goldman-Rakic, Patricia S.
中科院分区：
文献类型：
--
作者：
McGuire, Philip K.;Bates, Julianna F.;Goldman-Rakic, Patricia S.
在尾状核和壳核的猕猴额叶的成对的同伦区域的投影的终止区之间的关系进行了检查。在每个半球的主沟（PS）或辅助运动区（SMA）的地形匹配区域中注射WGA-HRP和氚化氨基酸，使得来自每侧相同区域的投影在同一动物中被差异标记。通过新纹状体的相邻部分处理各自的示踪剂，允许会聚projects之间的关系被defined.The地形分布和强度的同侧皮质纹状体预测观察单独标记的左，右半球是惊人的相似。从左侧和右侧PS的投影终止于中央部分的左侧和右侧新纹状体，分别优先，而预测的左侧和右侧SMA终止于各自的左侧和右侧新纹状体的背外侧部分。我们还比较了左右侧PS向同一新纹状体的投射。值得注意的是，无论是在左半球还是右半球，来自左右PS的投射都精确地记录在尾状核和壳核的特定地形区域。同样，左和右SMA的投影在左和右新纹状体中会聚。这种会聚允许在下行皮质纹状体网络中的半球间整合的显著程度。
The relationship between the termination zones of projections from paired homotopic areas of the frontal lobes was examined in the caudate nucleus and the putamen of the macaque monkey. Injections of WGA-HRP and tritiated amino acids were made in topographically matched regions of the principal sulcus (PS) or of the supplementary motor area (SMA) in each hemisphere, such that the projections from the same area on each side were differentially labeled in the same animal. Adjacent sections through the neostriatum were processed for the respective tracers, permitting the relationship between the converging projections to be defined.The topographic distribution and strength of ipsilateral corticostriatal projections observed for separately labeled left and right hemispheres were strikingly similar. Projections from the left and the right PS terminated preferentially in central parts of the left and right neostriata, respectively, while projections of the left and right SMAs terminated preferentially in dorsolateral parts of respective left and right neostriata. Therefore, little evidence for asymmetry of corticostriatal projections was found.The projections of the left and the right PS to the same neostriatum were also compared. Remarkably, whether in the left or right hemisphere, projections from the left and the right PS were in precise register in topographically specific territories of the caudate and putamen. Likewise, projections of the left and right SMAs converged in both the left and right neostriata. Such convergence allows for a remarkable degree of interhemispheric integration in the descending corticostriatal networks.