Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice
Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice
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DOI：
10.1016/j.jphs.2015.08.003
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发表时间：
2015-09-01
影响因子：
3.5
通讯作者：
Hinoi, Eiichi
中科院分区：
文献类型：
--
作者：
Ozaki, Kakeru;Okamoto, Maika;Hinoi, Eiichi
尽管β-隐黄质（一种叶黄素类胡萝卜素）已被证明对骨钙化具有合成代谢作用，但迄今为止，人们对骨重塑的精确机制却很少关注。每日口服β-隐黄质可显着抑制卵巢切除小鼠的破骨细胞活化以及骨体积减少。体外研究表明，β-隐黄质通过抑制核因子-κ B 依赖性转录途径来抑制破骨细胞的分化和成熟。我们的研究结果表明，补充β-隐黄质有利于预防和治疗与破骨细胞异常激活相关的代谢性骨疾病。 (C) 2015 年日本药理学会。由 Elsevier B.V. 代表日本药理学会制作和主办。
Although beta-cryptoxanthin, a xanthophyll carotenoid, has been shown to exert an anabolic effect on bone calcification, little attention has been paid thus far to the precise mechanism of bone remodeling. Daily oral administration of beta-cryptoxanthin significantly inhibited osteoclastic activation as well as reduction of bone volume in ovariectomized mice. In vitro studies revealed that beta-cryptoxanthin inhibited differentiation and maturation of osteoclasts by repression of the nuclear factor-kappa B-dependent transcriptional pathway. Our results suggest that supplementation with beta-cryptoxanthin would be beneficial for prophylaxis and for therapy of metabolic bone diseases associated with abnormal osteoclast activation. (C) 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B. V. on behalf of Japanese Pharmacological Society.