Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans.
Midbrain dopamine receptor availability is inversely associated with novelty-seeking traits in humans.
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DOI：
10.1523/jneurosci.2423-08.2008
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发表时间：
2008-12-31
期刊：
影响因子：
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通讯作者：
Kessler RM
中科院分区：
文献类型：
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作者：
Zald DH;Cowan RL;Riccardi P;Baldwin RM;Ansari MS;Li R;Shelby ES;Smith CE;McHugo M;Kessler RM
追求新奇的性格特征是滥用药物和其他不安全行为的主要风险因素。啮齿动物气质模型表明，高新奇反应与中脑多巴胺神经元的抑制性自身受体控制减弱有关。据推测，多巴胺功能的个体差异也是人类寻求新奇的个性特征的基础。然而，啮齿动物和人类的多巴胺系统的差异，以及评估跨物种新奇反应/寻求的方法的差异，尚不清楚动物模型在多大程度上影响了我们对人类性格的理解。在本研究中，我们研究了人类寻求新奇特征与黑质/腹侧被盖区 D2 样 (D2/D3) 受体可用性之间的相关性。根据啮齿动物文献，我们预测寻求新奇事物的特征是中脑中 D2 样（自身）受体可用性水平降低。 34 名健康成年人（18 名男性，16 名女性）完成了三维人格问卷-新奇寻求量表和使用 D2/D3 配体 [18F]fallypride 的 PET 扫描。寻求新奇的人格特质与腹侧中脑 D2 样受体的可用性呈负相关，这种效应在控制年龄后仍然显着。我们推测，高新奇探索者的中脑（自身）受体可用性较低，导致对新奇事物和其他诱导 DA 释放的条件的多巴胺能反应加剧。
Novelty seeking personality traits are a major risk factor for the development of drug abuse and other unsafe behaviors. Rodent models of temperament indicate that high novelty responding is associated with decreased inhibitory autoreceptor control of midbrain dopamine neurons. It has been speculated that individual differences in dopamine functioning also underlie the personality trait of novelty seeking in humans. However, differences in the dopamine system of rodents and humans, as well as the methods for assessing novelty responding/seeking across species leave unclear to what extent the animal models inform our understanding of human personality. In the present study we examined the correlation between novelty seeking traits in humans and D2-like (D2/D3) receptor availability in the substantia nigra/ventral tegmental area. Based on the rodent literature we predicted that novelty seeking would be characterized by lowered levels of D2-like (auto)receptor availability in the midbrain. 34 healthy adults (18 men, 16 women) completed the Tridimensional Personality Questionnaire-Novelty Seeking Scale and PET scanning with the D2/D3 ligand [18F]fallypride. Novelty seeking personality traits were inversely associated with D2-like receptor availability in the ventral midbrain, an effect that remained significant after controlling for age. We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce DA release.