Changes in the internal structure of the human crystalline lens with age and accommodation
Changes in the internal structure of the human crystalline lens with age and accommodation
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DOI：
10.1016/s0042-6989(03)00428-0
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发表时间：
2003-10-01
期刊：
影响因子：
1.8
通讯作者：
Vrensen, GFJM
中科院分区：
文献类型：
--
作者：
Dubbleman, M;Van der Heijde, GL;Vrensen, GFJM
Scheimpflug图像由102名年龄在16岁至65岁之间的受试者的未调节和调节的右眼制成。与早期的Scheimpflug研究相比，由于Scheimpflug相机的几何形状以及角膜和透镜本身的折射，图像被校正为失真。利用光密度测定法测定了人晶状体透镜的不同核层和皮质层，并研究了这些层的厚度如何随年龄和调节而变化。结果表明，随着年龄的增长，皮质厚度的增加大约是核厚度的7倍。发现前皮质厚度的增加是后皮质厚度的1.5倍。研究还发现，皮质的特定部分，称为C1和C3，随着年龄的增长，厚度没有明显变化，皮质的增厚完全是由于C2区厚度的增加。随着年龄的增长，沟（核的中心）和角膜之间的距离不会改变。随着调节，核变厚，但皮质的厚度保持不变。(C)2003爱思唯尔有限公司。保留所有权利。
Scheimpflug images were made of the unaccommodated and accommodated right eye of 102 subjects ranging in age between 16 and 65 years. In contrast with earlier Scheimpflug studies, the images were corrected for distortion due to the geometry of the Scheimpflug camera and the refraction of the cornea and the lens itself. The different nuclear and cortical layers of the human crystalline lens were determined using densitometry and it was investigated how the thickness of these layers change with age and accommodation. The results show that, with age, the increase in thickness of the cortex is approximately 7 times greater than that of the nucleus. The increase in thickness of the anterior cortex was found to be 1.5 times greater than that of the posterior cortex. It was also found that specific parts of the cortex, known as C1 and C3, showed no significant change in thickness with age, and that the thickening of the cortex is entirely due to the increase in thickness of the C2 zone. With age, the distance between the sulcus (centre of the nucleus) and the cornea does not change. With accommodation, the nucleus becomes thicker, but the thickness of the cortex remains constant. (C) 2003 Elsevier Ltd. All rights reserved.