The Human Cell Atlas.
The Human Cell Atlas.
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DOI：
10.7554/elife.27041
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发表时间：
2017-12-05
期刊：
影响因子：
7.7
通讯作者：
Yosef, Nir
中科院分区：
文献类型：
--
作者：
Regev, Aviv;Teichmann, Sarah A;Yosef, Nir
最近高通量单细胞分子图谱方法的出现在科学界催生了一种日益增长的感觉，即完成150年来识别人体所有细胞类型的努力的时机已经成熟。人类细胞图谱项目是一项国际合作努力，旨在根据独特的分子图谱(如基因表达图谱)定义所有人类细胞类型，并将这些信息与经典的细胞描述(如位置和形态)联系起来。一个开放的、全面的健康人体组织细胞分子状态参考图将推动对细胞生理状态、发育轨迹、调控回路和相互作用的系统研究，并为理解人类疾病中的细胞失调提供一个框架。在这里，我们描述了人类细胞地图集的想法、它的潜在效用、早期概念验证和一些设计考虑因素，包括对开放数据、代码和社区的承诺。
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body. The Human Cell Atlas Project is an international collaborative effort that aims to define all human cell types in terms of distinctive molecular profiles (such as gene expression profiles) and to connect this information with classical cellular descriptions (such as location and morphology). An open comprehensive reference map of the molecular state of cells in healthy human tissues would propel the systematic study of physiological states, developmental trajectories, regulatory circuitry and interactions of cells, and also provide a framework for understanding cellular dysregulation in human disease. Here we describe the idea, its potential utility, early proofs-of-concept, and some design considerations for the Human Cell Atlas, including a commitment to open data, code, and community.