Relative Efficacy of Alcohol and Propranolol in Action Tremor
Relative Efficacy of Alcohol and Propranolol in Action Tremor
复制标题
酒精和普萘洛尔对动作性震颤的相对功效
DOI：
10.1017/s0317167100019958
复制
发表时间：
1975
期刊：
影响因子：
--
通讯作者：
A. Quraishi
中科院分区：
文献类型：
--
作者：
A. Rajput;H. Jamieson;S. Hirsh;A. Quraishi
总结：39例患有各种疾病的患者，包括特发性震颤、帕金森氏病、橄榄脑桥小脑变性、共济失调毛细血管扩张症和颈髓损伤伴动作性震颤，评价了摄入1盎司无水酒精的效果。61.9%的E.T.患者震颤明显消退; P.D.占46.6%; 1例AT患者; C6病变1例。1例O.P.C.D.患者的震颤加重。其中20例患者接受普萘洛尔治疗，平均剂量为92毫克。每天，并在三到六个月后重新评估。所有那些酒精改善的人都改善了普萘洛尔，而酒精加重震颤的人对普萘洛尔有类似的反应。它的结论是，tremorilytic效果的酒精既不是特定的，也不限于，特发性震颤，是没有价值的区分各种神经系统疾病表现为动作震颤。建议将口服一盎司无水酒精作为一种办公室程序来预测患者对普萘洛尔的反应。
SUMMARY: Thirty-nine patients with a variety of diseases, including essential tremor, Parkinsonߣs Disease, olivopontocerebellar degeneration, ataxia telangiectasia, and cervical cord injury with action tremor, were evaluated for the effect of one ounce of absolute alcohol ingestion. Tremor significantly subsided in 61.9% of E.T.; 46.6% of P.D.; one patient with A.T.; and one patient with C6 lesion. The tremor became worse in one patient with O.P.C.D. Twenty of these patients were treated with propranolol, an average dose of 92 mgm. per day, and re-evaluated three to six months later. All those who improved on alcohol improved on propranolol and the one whose tremor accentuated with alcohol had a similar response to propranolol. It is concluded that the tremorilytic effect of alcohol is neither specific for, nor limited to, essential tremor and is of no value in differentiating various neurological disorders which manifest as action tremor. It is recommended that one ounce of absolute alcohol by mouth be used as an office procedure to predict the response of patientsߣ tremor to propranolol.