The function of cathepsins B, D, and X in atherosclerosis.
The function of cathepsins B, D, and X in atherosclerosis.
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DOI：
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发表时间：
2016
影响因子：
1.3
通讯作者：
Caroline Zhao;D. Herrington
中科院分区：
文献类型：
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作者：
Caroline Zhao;D. Herrington
组织蛋白酶是一种蛋白水解酶，通常位于巨噬细胞的溶酶体内。一旦释放，它们可以增强动脉粥样硬化的炎症过程。组织蛋白酶X有助于t淋巴细胞的迁移和细胞因子的释放。组织蛋白酶D修饰低密度脂蛋白，促进其被巨噬细胞摄取和随后的泡沫细胞形成。此外，组织蛋白酶D调节细胞凋亡。组织蛋白酶B降解动脉内膜内的细胞外基质。它们共同增加了斑块的脆弱性。这表明组织蛋白酶在动脉粥样硬化的发病机制中起重要作用。
Cathepsins are proteolytic enzymes typically located within the lysosomes of macrophages. Once released, they can enhance the inflammatory process in atherosclerosis. Cathepsin X aids in the migration of T-lymphocytes and the release of cytokines. Cathepsin D modifies low-density lipoprotein to promote its uptake by macrophages and its subsequent foam cell formation. Furthermore, cathepsin D regulates apoptosis. Cathepsin B degrades the extracellular matrix within the arterial intima. Together, they increase plaque vulnerability. This evidence suggests that cathepsins play an important role in the pathogenesis of atherosclerosis.