SIMULTANEOUS CHANGES IN HYPOTHALAMIC CATECHOLAMINE LEVELS AND PLASMA-CORTICOSTERONE CONCENTRATION IN THE RAT AFTER ACUTE MORPHINE AND DURING TOLERANCE
SIMULTANEOUS CHANGES IN HYPOTHALAMIC CATECHOLAMINE LEVELS AND PLASMA-CORTICOSTERONE CONCENTRATION IN THE RAT AFTER ACUTE MORPHINE AND DURING TOLERANCE
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DOI：
10.1016/0143-4179(93)90016-4
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发表时间：
1993-05-01
期刊：
影响因子：
2.9
通讯作者：
VARGAS, ML
中科院分区：
文献类型：
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作者：
MILANES, MV;PUIG, MM;VARGAS, ML
在幼稚大鼠和吗啡耐受大鼠中研究吗啡对血浆皮质酮、下丘脑去甲肾上腺素 (NA) 和多巴胺 (DA) 含量的影响。急性给予吗啡（30 mg/kg i.p.）显着增加血浆皮质酮水平，并显着降低下丘脑 NA 和 DA 含量。在长期吗啡治疗的大鼠（皮下植入颗粒 7 天）中，吗啡攻击剂量（30 mg/kg 腹腔注射 (i.p.)）不会改变血浆皮质酮水平，并抑制吗啡诱导的下丘脑 NA 和 DA 含量下降。这些结果表明：（1）在初始大鼠中，吗啡诱导的下丘脑 - 垂体 - 肾上腺皮质的激活(HPA) 轴由下丘脑中的儿茶酚胺能神经元介导； (2) 在耐受大鼠中，吗啡不会改变血浆皮质酮浓度，可能是通过减弱下丘脑去甲肾上腺素能和多巴胺能活性。 (3)下丘脑儿茶酚胺在吗啡耐受过程中具有调节HPA轴的作用。
The effects of morphine on plasma corticosterone and hypothalamic noradrenaline (NA) and dopamine (DA) content were studied in naive and in morphine-tolerant rats. Acutely administered morphine (30 mg/kg i.p.) significantly increased the plasma levels of corticosterone and significantly reduced the hypothalamic NA and DA content. In chronically morphine-treated rats (subcutaneously implanted with pellets for 7 days), a challenge dose of morphine (30 mg/kg intraperitoneally (i.p.)) did not modify the plasma corticosterone levels and inhibited the morphine-induced decreases in hypothalamic NA and DA content.These results suggest that: (1) In naive rats, the morphine-induced activation of hypothalamus- pituitary- adrenocortical (HPA) axis is mediated by catecholaminergic neurons in the hypothalamus; (2) In tolerant rats morphine did not modify the plasma corticosterone concentrations, presumably by attenuating hypothalamic noradrenergic and dopaminergic activity. (3) Hypothalamic catecholamines have a role in regulating the HPA axis during morphine tolerance.