TNF-INDUCING MALARIA TOXIN - A SHEEP IN WOLFS CLOTHING
TNF-INDUCING MALARIA TOXIN - A SHEEP IN WOLFS CLOTHING
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DOI：
10.1080/00034983.1993.11812819
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发表时间：
1993-12-01
影响因子：
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通讯作者：
KWIATKOWSKI, D
中科院分区：
文献类型：
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作者：
KWIATKOWSKI, D
长期以来，人们一直认为疟疾热的发作是由于一种毒素从破裂的疟原虫中释放出来。人们开始了解这种毒素的性质。疟疾热的一个关键介质是肿瘤坏死因子（TNF），它由单核细胞/巨噬细胞释放，是一种强效热原。破裂的巨噬细胞释放一种或多种毒素，刺激巨噬细胞释放TNF。该毒素的确切结构尚不清楚，但似乎涉及磷脂酰肌醇样部分。除了引起发热外，TNF诱导毒素被认为参与脑型疟疾的发病机制。然而，脑型疟疾只发生在一小部分受感染的个体中;对于整个人群来说，TNF对疟疾毒素的反应的益处可能大于其缺点。
It has long been believed that paroxysms of malaria fever are due to a toxin released by rupturing schizonts. The nature of this toxin is beginning to be understood. A critical mediator of malaria fever is tumour necrosis factor (TNF), which is released by monocytes/macrophages and is a potent pyrogen. Rupturing schizonts release a toxin (or toxins) that stimulate macrophages to release TNF. The precise structure of the toxin is unknown but it appears to involve a phosphatidylinositol-like moiety. In addition to causing fever, TNF-inducing toxins are believed to be involved in the pathogenesis of cerebral malaria. However, cerebral malaria occurs in only a small proportion of infected individuals; for the population as a whole, the benefits of the TNF response to the malaria toxin probably outweigh its disadvantages.