Effects of oxytocin on recollections of maternal care and closeness
Effects of oxytocin on recollections of maternal care and closeness
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DOI：
10.1073/pnas.1012669107
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发表时间：
2010-12-14
影响因子：
11.1
通讯作者：
Lydon, John E.
中科院分区：
文献类型：
--
作者：
Bartz, Jennifer A.;Zaki, Jamil;Lydon, John E.
虽然婴儿-看护者依恋关系对婴儿的生存至关重要，但人们对支持人类依恋表征的生物学机制知之甚少。催产素在动物依恋关系的形成和维持中起着关键作用，因此可以预期会影响人类的依恋表征。为了研究这种可能性，我们在一项双盲、安慰剂对照、交叉设计的研究中给健康成年男性鼻内注射24 IU催产素，然后评估童年母亲护理和亲密的记忆-依恋纽带的两个特征。我们发现，催产素的影响受到人们所拥有的依恋表征的调节，焦虑依恋较少的人记得他们的母亲更关心和接近催产素（与安慰剂相比），而焦虑依恋较多的人记得他们的母亲不太关心和接近催产素（与安慰剂相比）。这些数据与流行的观点形成对比，即催产素对社会感知具有广泛的积极影响，并且与动物文献更加一致，后者强调催产素在编码社会记忆中的作用，并将这些记忆与社会刺激的奖励价值联系起来。
Although the infant-caregiver attachment bond is critical to survival, little is known about the biological mechanisms supporting attachment representations in humans. Oxytocin plays a key role in attachment bond formation and maintenance in animals and thus could be expected to affect attachment representations in humans. To investigate this possibility, we administered 24 IU intranasal oxytocin to healthy male adults in a double-blind, placebo-controlled, crossover designed study and then assessed memories of childhood maternal care and closeness-two features of the attachment bond. We found that the effects of oxytocin were moderated by the attachment representations people possess, with less anxiously attached individuals remembering their mother as more caring and close after oxytocin (vs. placebo) but more anxiously attached individuals remembering their mother as less caring and close after oxytocin (vs. placebo). These data contrast with the popular notion that oxytocin has broad positive effects on social perception and are more consistent with the animal literature, which emphasizes oxytocin's role in encoding social memories and linking those memories to the reward value of the social stimulus.