Oral cancer in Southern India:: The influence of smoking, drinking, paan-chewing and oral hygiene
Oral cancer in Southern India:: The influence of smoking, drinking, paan-chewing and oral hygiene
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DOI：
10.1002/ijc.10200
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发表时间：
2002-03-20
影响因子：
6.4
通讯作者：
Franceschi, S
中科院分区：
文献类型：
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作者：
Balaram, P;Sridhar, H;Franceschi, S
1996年至1999年，我们在印度南部的3个地区（班加罗尔、马德拉斯和特里凡得琅）进行了一项病例对照研究，包括591例口腔癌发病病例（282名妇女）和582例医院对照（290名妇女），按年龄和性别与病例频率相匹配。优势比（OR）和95%置信区间（CI）来自无条件多元Logistic回归，并根据年龄、性别、中心、教育、咀嚼习惯和（仅限男性）吸烟和饮酒习惯进行调整。受教育程度低、职业为农民或体力劳动者以及口腔卫生不良的各种指标与风险显著增加相关。男性吸烟量大于或等于20 bidi或等效物与0/天的OR为2.5（95% CI 1.4-4.4）。饮酒的OR为2.2（95%CI 1.4-3.3）。女性（OR 42; 95% CI 24-76）咀嚼面包的OR高于男性（OR 5.1; 95% CI 3.4-7.8）。在有烟草（男性OR 6.1，女性OR 46）和没有烟草（男性OR 4.2，女性OR 16.4）的咀嚼者中发现了类似的OR。在男性中，35%的口腔癌可归因于吸烟和饮酒的结合，49%归因于嚼烟草。在女性中，咀嚼和口腔卫生不良解释了95%的口腔癌。(C)2002 Wiley-Liss，Inc.
Between 1996 and 1999 we carried out a case-control study in 3 areas in Southern India (Bangalore, Madras and Trivandrum) including 591 incident cases of cancer of the oral cavity (282 women) and 582 hospital controls (290 women), frequency-matched with cases by age and gender. Odds ratios (ORs) and 95% confidence intervals (CIs) were obtained from unconditional multiple logistic regressions and adjusted for age, gender, center, education, chewing habit and (men only) smoking and drinking habits. Low educational attainment, occupation as a farmer or manual worker and various indicators of poor oral hygiene were associated with significantly increased risk. An OR of 2.5 (95% CI 1.4-4.4) was found in men for smoking greater than or equal to 20 bidi or equivalents versus 0/day. The OR for alcohol drinking was 2.2 (95% CI 1.4-3.3). The OR for paan chewing was more elevated among women (OR 42; 95% CI 24-76) than among men (OR 5.1; 95% CI 3.4-7.8). A similar OR was found among chewers of paan with (OR 6.1 in men and 46 in women) and without tobacco (OR 4.2 in men and 16.4 in women). Among men, 35% of oral cancer is attributable to the combination of smoking and alcohol drinking and 49% to pan-tobacco chewing. Among women, chewing and poor oral hygiene explained 95% of oral cancer. (C) 2002 Wiley-Liss, Inc.