Cancer chemopreventive activity of terpenoid Coumarins from Ferula species
Cancer chemopreventive activity of terpenoid Coumarins from Ferula species
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DOI：
10.1055/s-2008-1034293
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发表时间：
2008-02-01
期刊：
影响因子：
2.7
通讯作者：
Itoigawa, Masataka
中科院分区：
文献类型：
--
作者：
Iranshahi, Mehrdad;Kalategi, Farhad;Itoigawa, Masataka
几种天然产物已被发现具有抗肿瘤促进活性。在本研究中，我们对从阿魏属植物中分离到的10种萜类香豆素进行了初步筛选，研究了它们对12-O-十四酰佛波醇13-乙酸酯(TPA)诱导Raji细胞中EB病毒早期抗原(EBV-EA)激活的可能抑制作用。金莲烯(7-香叶氧基香豆素，1)和伞形花素(7-法尼氧基香豆素，2)可显著抑制EBV-EA的激活，并维持Raji细胞的高活性，提示它们可能分别是有价值的抗肿瘤促进剂IC50 8.3和9.1 nM。我们的发现表明，萜类香豆素中存在的戊烯基部分在抗肿瘤活性中起着重要的作用，就像先前报道的xanthone、香豆素、黄酮类和苯丙素类化合物一样。
Several natural products have been found to have anti-tumor promoting activity. In the present study, we carried out a primary screening of ten terpenoid coumarins isolated from plants of the Ferula species, examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. Auraptene (7-geranyloxycoumarin, 1) and umbelliprenin (7-farnesyloxycoumarin, 2) were found to significantly inhibit EBV-EA activation and pre-served the high viability of Raji cells, suggesting that they might be valuable anti-tumor-promoting agents IC50 8.3 and 9.1 nM, respectively). Our findings revealed that the presence of a prenyl moiety in the terpenoid coumarins plays an important role in anti-tumor promoting activity as previously reported for xanthones, coumarins, flavonoids and phenylpropanoids.