Health-related quality of life in Parkinson's disease: A study of outpatient clinic attenders
Health-related quality of life in Parkinson's disease: A study of outpatient clinic attenders
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DOI：
10.1002/mds.870120613
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发表时间：
1997-11-01
影响因子：
8.6
通讯作者：
Hyman, N
中科院分区：
文献类型：
--
作者：
Fitzpatrick, R;Peto, V;Hyman, N
目标：评估的有效性和响应性的问卷调查，以评估健康相关的生活质量在帕金森氏病（PD）-39项帕金森氏病问卷（PDQ-39）-和报告的问题所经历的患者通过的questionnaire.Methods：患者完成了PDQ-39和SF-36在基线和4个月后。在相同的评估，神经科医生评定患者与Hoehn和Yahr和哥伦比亚Scales.Results：证据的有效性的新的问卷调查观察到的协议的分数与临床量表在两个评估。从基线和随访评分之间差异的显著配对t检验以及与患者回顾性判断和SF-36总分变化的相关性中观察到评估身体功能（特别是活动性和日常生活活动）的量表反应性证据，但是，与神经科医生临床评分变化无显著相关性。在PDQ-39中，患者最常报告身体功能问题。PDQ-39的几个维度的分数显着更有利的非临床样本的PD患者的报告。结论：PDQ-39的有效性，用于神经科门诊治疗PD的患者。也有一些证据表明反应迅速。该问卷确定的问题是重要的病人，似乎是更常见的非诊所就诊者经历。
Objective: To assess the validity and responsiveness of a questionnaire to assess health-related quality of life in Parkinson's disease (PD)-the 39-item Parkinson's Disease Questionnaire (PDQ-39)-and to report problems experienced by patients by means of the questionnaire.Methods: Patients completed the PDQ-39 and the SF-36 at baseline and 4 months later. At the same assessments, neurologists rated patients with Hoehn and Yahr and Columbia Scales.Results: Evidence for validity of the new questionnaire was observed by agreement of scores with clinical scales at both assessments. Evidence for responsiveness of scales assessing physical function, particularly mobility and activities of daily living, was observed from significant paired t tests for differences between scores at baseline and follow-up, and correlations with patients' retrospective judgments and changes in the SF-36 summary scores, However, there were no significant associations with changes in neurologists' clinical scores. Patients most frequently reported problems of physical function in the PDQ-39. Scores for several dimensions of the PDQ-39 were significantly more favorable than those reported by nonclinic samples of patients with PD.Conclusions: The PDQ-39 has validity for use among patients attending neurological clinics for treatment of PD. There is also some evidence of responsiveness. The questionnaire identifies problems that are important to patients and that appear to be more commonly experienced by nonclinic attenders.