Effect of nonsteroidal anti-inflammatory agents and finasteride on prostate cancer risk
Effect of nonsteroidal anti-inflammatory agents and finasteride on prostate cancer risk
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DOI：
10.1016/s0022-5347(05)64277-2
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发表时间：
2002-11-01
影响因子：
6.6
通讯作者：
Haillot, O
中科院分区：
文献类型：
--
作者：
Irani, J;Ravery, V;Haillot, O
目的：探讨非甾体类抗炎药和非那雄胺与前列腺癌发病的关系。材料和方法：本病例对照研究的参与者采用前瞻性数据收集，来自1999年1月至2000年6月在12个不同泌尿科接受前列腺活检的连续患者。药物使用情况通过自我调查问卷以及可能与前列腺癌风险相关的饮食和生活方式因素进行评估。结果：该研究包括639例前列腺癌患者和659例无癌对照。单因素分析显示阿司匹林和非那雄胺对前列腺癌风险无显著影响，而非阿司匹林非甾体抗炎药使用者的风险较低（OR 0.80, 95% CI 0.64-0.99）。在调整潜在混杂因素后，非阿司匹林非甾体类抗炎药的保护作用不再显著（OR, 0.84, 95% CI 0.66-1.07），而非那雄胺显示出显著的保护作用（OR 0.58, 95% CI 0.37-0.92）。结论：非那雄胺对前列腺癌具有化学预防作用。虽然阿司匹林没有显示出对前列腺癌风险的任何影响，但非阿司匹林非甾体抗炎药的作用值得进一步研究。
Purpose: We examine the relationship of nonsteroidal anti-inflammatory drugs and finasteride on the risk of prostate cancer.Materials and Methods: Participants in this case control study using a prospective collection of data were drawn from consecutive patients who underwent prostate biopsy at 12 different departments of urology from January 1999 to June 2000. Medication use was assessed by self-questionnaire as well as questions about dietary and lifestyle factors that might be relevant for prostate cancer risk.Results: The study included 639 patients with prostate cancer and 659 cancer-free controls. Univariate analysis showed no significant impact of aspirin and finasteride on prostate cancer risk while the nonaspirin nonsteroidal anti-inflammatory drug users had a lower risk (OR 0.80, 95% CI 0.64-0.99). After adjusting for potential confounders, the protective effect of nonaspirin nonsteroidal anti-inflammatory drugs was no longer significant (OR, 0.84, 95% CI 0.66-1.07), while finasteride showed a significant protective effect (OR 0.58, 95% CI 0.37-0.92).Conclusions: The results suggest that finasteride could have a chemopreventive role in prostate cancer. While aspirin did not show any impact on prostate cancer risk, the role of nonaspirin nonsteroidal anti-inflammatory drugs warrants further studies.