Similar carcinogenic effects in rats of 1-ethyl-1-nitroso-3-hydroxyethylurea and 1-hydroxyethyl-1-nitroso-3-ethylurea.
Similar carcinogenic effects in rats of 1-ethyl-1-nitroso-3-hydroxyethylurea and 1-hydroxyethyl-1-nitroso-3-ethylurea.
复制标题
1-乙基-1-亚硝基-3-羟乙基脲和1-羟乙基-1-亚硝基-3-乙基脲对大鼠有相似的致癌作用。
DOI：
10.1093/carcin/6.4.641
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发表时间：
1985
期刊：
影响因子：
4.7
通讯作者：
Kovatch,RM
中科院分区：
文献类型：
--
作者：
Lijinsky,W;Singer,GM;Kovatch,RM
以等摩尔剂量对20只雄性F344大鼠灌胃给予二烷基脲的两种同分异构体N-亚硝基衍生物1-乙基-3-（2-羟乙基）脲30周。将致瘤反应与类似剂量的亚硝基乙基脲或亚硝基-2-羟乙基脲进行比较。每一种亚硝基单烷基脲都比类似的亚硝基二烷基脲更快地引起肿瘤死亡。与亚硝基乙基脲或亚硝基-2-羟乙基脲相比，每种亚硝基二烷基脲在大鼠中诱导的肿瘤谱更广，包括甲状腺、肺、皮肤、结肠、间皮瘤以及脑和肝肿瘤的高发病率，其中后两种在给予亚硝基单烷基脲的动物中未观察到。另一方面，给予亚硝基二烷基脲类的大鼠前胃肿瘤比给予亚硝基非烷基脲类的大鼠少。1-亚硝基-1-乙基-3-羟乙基脲和1-亚硝基-1-羟乙基-3-乙基脲之间的主要差异是，前者仅在30%的大鼠肝脏中诱导肿瘤结节，而后者在55%的大鼠中诱导肝细胞癌;给予任一化合物的大鼠中约有一半患有脑肿瘤，包括星形细胞瘤、神经胶质瘤和少突胶质瘤。
The two isomeric N-nitroso derivatives of the dialkylurea, 1-ethyl-3-(2-hydroxyethyl)urea, were given by gavage to 20 male F344 rats for 30 weeks at equimolar doses. The tumorigenic responses were compared with those to a similar dose of nitrosoethylurea or nitroso-2-hydroxyethylurea. Each of the nitrosomonoalkylureas caused death from tumors more rapidly than the analogous nitrosodialkylurea. Each of the nitrosodialkylureas induced a broader spectrum of tumors in the rats than did either nitrosoethylurea or nitroso-2-hydroxyethylurea, including neoplasms of the thyroid, lung, skin, colon, mesotheliomas and neoplasms of the brain and liver in high incidence, the last two of which were not seen in animals given the nitrosomonoalkylureas. On the other hand, there were fewer tumors of the forestomach in rats given the nitrosodialkylureas than with the nitrosomo-noalkylureas. The major difference between 1-nitroso-1-eth-yl-3-hydroxyethylurea and 1-nitroso-1-hydroxyethyl-3-ethyl- urea was that the former induced only neoplastic nodules in the,liver of 30% of the rats, while the latter induced hepatocellular carcinomas in 55% of the rats; approximately half of the rats given either compound had brain neoplasms, which included astrocytomas, gliomas and oligoden drogliomas.