Dickkopf-1 Expression During Early Bovine Placentation and Its Downregulation in Somatic Cell Nuclear Transfer (SCNT) Pregnancies
Dickkopf-1 Expression During Early Bovine Placentation and Its Downregulation in Somatic Cell Nuclear Transfer (SCNT) Pregnancies
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DOI：
10.1262/jrd.20142
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发表时间：
2009-10-01
影响因子：
1.8
通讯作者：
Peterson, Jim
中科院分区：
文献类型：
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作者：
Ledgard, Anita;Lee, Rita S-F.;Peterson, Jim
Dickkopf-1（Dkk-1）在早期牛滋养层发育和随后的胎盘形成过程中的确切作用尚未完全了解。使用体细胞核移植（SCNT）产生的妊娠作为不良胎盘形成的模型，我们发现在妊娠第50天SCNT胎儿子叶组织中Dkk-1 mRNA的平均水平比人工授精（AI）产生的那些低1.5倍。在第100天和第150天降低2倍（P
The precise role of Dickkopf-1 (Dkk-1) during early bovine trophoblast development and subsequent placentation is not fully understood. Using somatic cell nuclear transfer (SCNT) generated pregnancies as a model of poor placentation we have found that mean levels of Dkk-1 mRNA were 1.5 fold lower in SCNT fetal cotyledon tissue at Day 50 of gestation than those resulting from artificial insemination (AI.) and 2 fold lower at Days 100 and 150 (P