Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens.

Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens.
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真菌病原体的预期应激反应和免疫逃避。

DOI:
10.1016/j.tim.2020.09.010
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发表时间:
2021
影响因子:
15.9
通讯作者:
Pradhan A
Pradhan A
中科院分区:
生物学1区
文献类型:
--
作者:
Pradhan A

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在某些生态位中,微生物会遇到时间上相关的环境挑战。在这种情况下,微生物适应性通过预期反应的进化而增强,其中初始挑战同时激活针对第二次即将到来的挑战的先发制人的保护。驯化酵母中预期反应的积累(被称为“适应性预测”)导致了提供应激交叉保护的“核心应激反应”的出现。保护性预期反应在人类真菌病原体中也很常见。这些反应反映了这些真菌在其进化史上最近所面临的选择压力。因此,一些病原体已经进化出“核心环境反应”,这些反应利用宿主信号来触发免疫逃避策略,以保护它们免受即将到来的免疫攻击。
In certain niches, microbes encounter environmental challenges that are temporally linked. In such cases, microbial fitness is enhanced by the evolution of anticipatory responses where the initial challenge simultaneously activates pre-emptive protection against the second impending challenge. The accumulation of anticipatory responses in domesticated yeasts, which have been termed 'adaptive prediction', has led to the emergence of 'core stress responses' that provide stress cross-protection. Protective anticipatory responses also seem to be common in fungal pathogens of humans. These responses reflect the selective pressures that these fungi have faced relatively recently in their evolutionary history. Consequently, some pathogens have evolved 'core environmental responses' which exploit host signals to trigger immune evasion strategies that protect them against imminent immune attack.
在低氧气环境中逃避免疫监测会增强白色念珠菌的毒力。
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影响因子: 6.4
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