PERFLUOROETHER LIQUID AS A LONG-TERM VITREOUS SUBSTITUTE: An Experimental Study
PERFLUOROETHER LIQUID AS A LONG-TERM VITREOUS SUBSTITUTE: An Experimental Study
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全氟醚液体作为长期玻璃替代品：实验研究
DOI：
10.1097/00006982-198400440-00010
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. Albert
中科院分区：
文献类型：
--
作者：
K. Miyamoto;M. Refojo;F. Tolentino;G. Fournier;D. Albert
A commercial perfluoroether liquid, Fomblin®-H Fluorinated Fluid, which is transparent and viscous, was investigated as a possible long-term vitreous substitute. The material belongs to a family of perfluorocarbon derivatives that are generally inert and nontoxic. A space for the vitreous substitute was created in rabbit eyes by a vitreous compression technique using perfluoropropane gas. Fomblin caused gliosis of the retina at 1 month after intravitreous injection. Preretinal membrane formation and retinal disorganization and detachment occurred in two of four eyes enucleated at 3 months, and in all five eyes enucleated at 4 or 6 months. Vacuoles presumably filled with Fomblin were localized histopathologically within the retina. In control eyes injected with medical-grade silicone oil, abnormalities were limited to moderate edema of the nerve fiber and ganglion cell layer. Fomblin was not as well-tolerated by the rabbit retina as was medical-grade silicone oil. Fomblin is not a suitable vitreous substitute.
