Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+: The 90+ Study.
Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+: The 90+ Study.
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四分之一世纪后 90 岁时自我报告的睡眠与痴呆风险的关系：90 年研究。
DOI：
10.1080/15402002.2022.2148668
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发表时间：
2023
影响因子：
3.1
通讯作者：
Corrada,MaríaM
中科院分区：
文献类型：
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作者：
Melikyan,ZaruiA;Kawas,ClaudiaH;Paganini-Hill,Annlia;Jiang,Luohua;Mander,BryceA;Corrada,MaríaM
目的研究平均年龄为69岁的女性自我报告的睡眠时间和午睡的性别特异性相关性（范围：53-81）与24年后在90岁以上时发生痴呆症的风险。方法分析样本包括来自一项基于人群的研究的个体，他们在20世纪80年代和24年后报告了一次睡眠和午睡（范围：16-38）参加了90+研究，并进行了评估的人。前瞻性随访了90+研究基线时无痴呆的患者。风险比[HR]和95%置信区间[CI]的痴呆风险估计考克斯regression.ResultsOf 574参与者71%是女性，平均年龄在开始痴呆随访与90+ Studywas 93岁（范围：90-102）。经过3.3年（范围：0.4-13.8）的随访，47%的人患上了痴呆症。与每晚8小时的自我报告睡眠时间相比，90岁以上的女性患痴呆症的风险更高（调整后的HR = 2.00; 95% CI = 1.15-3.50;p= 0.01）。在90岁以上的老年痴呆症的风险较低的男性与短期至中度（<60分钟）自我报告的午睡相比，没有午睡（HR = 0.33; 95%CI = 0.18-0.63;p<0.01）。
ObjectiveTo examine sex-specific associations of sleep duration and napping self-reported at mean age of 69 years (range: 53–81) with risk of incident dementia 24 years later at age 90 +.MethodAnalytic sample included individuals from a population-based study who reported sleep and napping once in the 1980s and 24 years later (range: 16–38) joinedThe 90+ Studyand were evaluated in-person. Those without dementia at baseline ofThe 90+ Studywere prospectively followed. Hazard ratios [HR] and 95% confidence intervals [CI] of dementia risk were estimated by Cox regression.ResultsOf 574 participants 71% were women, mean age at start of dementia follow-up withThe 90+ Studywas 93 years (range: 90–102). After 3.3 years (range: 0.4–13.8) of follow-up 47% developed dementia. Higher risk of dementia at age 90+ was seen in women with <6 hours of self-reported sleep per night (adjusted HR = 2.00; 95% CI = 1.15–3.50;p= .01) compared with 8 hours. Lower risk of dementia at 90+ was seen in men with short-to-moderate (<60 minutes) self-reported naps compared with no naps (HR = 0.33; 95% CI = 0.18–0.63;p< .01).ConclusionsSleep and nap 24 years earlier are important risk factors for dementia after age 90.