MECHANICAL PROPERTIES OF TISSUES OF LATHYRITIC ANIMALS
MECHANICAL PROPERTIES OF TISSUES OF LATHYRITIC ANIMALS
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DOI：
10.1113/jphysiol.1962.sp007003
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发表时间：
1962-01-01
影响因子：
5.5
通讯作者：
HARKNESS, ML
中科院分区：
文献类型：
--
作者：
FRY, P;HARKNESS, RD;HARKNESS, ML
已经测量了lasterotic动物组织的胶原蛋白含量和某些机械性质;皮肤，肠和主动脉来自喂食含有甜豌豆粉的饮食的大鼠，以及皮肤来自将[β]-氨基丙腈注射到鸡蛋中的小鸡。胶原蛋白的浓度被发现没有显着差异，在正常和lavitic组织。拉张强度，计算每单位的胶原蛋白的横截面积，在皮肤和主动脉的lavitic大鼠约为正常动物的一半。在皮肤中，LATERONIC雏鸡约为正常雏鸡的五分之一。在正常大鼠和腹泻动物的肠道中没有发现差异。组织的“伸展性”通过伸展速率测量，在此之后，在恒定载荷下伸展速率变为恒定，校正为标准张力/胶原的单位横截面积。在大鼠的皮肤和肠道中，正常组织和患淋巴炎的组织之间没有差异，但患淋巴炎的雏鸡的皮肤的伸展性比正常组织大约15倍。有证据表明，这种延展性的差异与胶原框架的大小无显著差异有关，这表明延展性不是后者生长的限制因素。
Measurements have been made of the collagen content and some mechanical properties of tissues of lathyritic animals; skin, intestine and aorta from rats fed on a diet containing sweet-pea meal, and skin from chicks after injection of [beta]-amino propionitrile into the eggs. The concentration of collagen was found not to differ significantly in the normal and lathyritic tissues. Tensile strength, calculated per unit cross-sectional area of collagen, in skin and aorta of lathyritic rats was about half that in normal animals. In skin of lathyritic chicks it was about one fifth that in normal chicks. In intestine of rats no difference was found between normal and lathyritic animals. The "extensibility" of the tissues was measured by the rate of extension, after this had become constant under a constant load, corrected to standard tension/unit cross-sectional area of collagen. No differences between normal and lathyritic tissues were found in skin and intestine of rats, but extensibility was about fifteen times greater in the skin from lathyritic chicks than from normal ones. Evidence was obtained that this difference in extensibility was associated with no significant difference in the size of the collagenous framework, which suggests that extensibility is not a limiting factor in the growth of the latter.