Cocaine-induced suppression of saccharin intake: A model of drug-induced devaluation of natural rewards
Cocaine-induced suppression of saccharin intake: A model of drug-induced devaluation of natural rewards
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DOI：
10.1037/0735-7044.116.2.321
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发表时间：
2002-04-01
影响因子：
1.9
通讯作者：
Twining, RC
中科院分区：
文献类型：
--
作者：
Grigson, PS;Twining, RC
在实验1中，剥夺水分的Sprague-Dawley大鼠给予5分钟的糖精接触时间。该管收回，一根空管进入，大鼠被给予1小时舔空管，以固定比例舔10次，通过静脉导管自行给予生理盐水或可卡因（0.33毫克/次）。结果表明，在糖精-可卡因配对后，大鼠避免摄入糖精，并且更大程度地避免味觉提示与更大程度的可卡因自我给药有关。在实验2中，以空管或杠杆为操作对象，得到了类似的剂量-响应函数。在实验3中，对糖精线索的回避和自我使用可卡因的倾向在禁欲至少1个月后保持不变。因此，这一范式可以作为线索诱导的渴望和药物诱导的自然奖励贬值的模型。
In Experiment 1, water-deprived Sprague-Dawley rats were given 5 min access to saccharin. This tube retracted, an empty tube advanced, and the rats were given 1 hr to lick the empty tube on a fixed-ratio 10 lick contingency to self-administer saline or cocaine (0.33 mg/infusion) via an intravenous catheter. The results showed that rats avoided intake of saccharin after saccharin-cocaine pairings and that greater avoidance of the gustatory cue was associated with greater cocaine self-administration. In Experiment 2, a similar dose-response function was obtained with either the empty tube or a lever as the operant. In Experiment 3, avoidance of the saccharin cue and the propensity to self-administer cocaine were maintained after at least 1 month of abstinence. As such, this paradigm may be useful as a model of cue-induced craving and drug induced devaluation of natural rewards.