Absent or Delayed Preovulatory Luteinizing Hormone Surge in Experimental Diabetes Mellitus
Absent or Delayed Preovulatory Luteinizing Hormone Surge in Experimental Diabetes Mellitus
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实验性糖尿病中排卵前黄体生成激素激增缺失或延迟
DOI：
10.2337/diab.33.4.324
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发表时间：
1984
期刊：
影响因子：
7.7
通讯作者：
K. Shimaoka
中科院分区：
文献类型：
--
作者：
S. Katayamá;C. Brownscheidle;V. Wootten;J. B. Lee;K. Shimaoka
超过56%的未经治疗的链脲佐菌素糖尿病大鼠的发情前期排卵前促黄体生成激素（LH）峰不存在或延迟。无LH峰与无排卵相关。胰岛素治疗10-14天恢复了减少的峰和排卵频率。糖尿病大鼠对外源性促性腺激素释放激素的反应性黄体生成素释放与对照组无差异。下丘脑功能受损可能是糖尿病不孕症发病率增加的基础。
The proestrus preovulatory luteinizing hormone (LH) surge was absent or delayed in more than 56% of untreated streptozotocin-diabetic rats. Absence of LH surge was associated with anovulation. Insulin treatment for 10–14 days restored the diminished surge and ovulation frequency. Pituitary LH release in response to exogenous gonadotropin-releasing hormone administration in diabetic rats was not different from controls. Impaired hypothalamic function may comprise the basis for the increased incidence of infertility in diabetes mellitus.