Is Kawasaki disease an infectious disorder?
Is Kawasaki disease an infectious disorder?
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DOI：
10.1111/1756-185x.13213
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发表时间：
2018-01-01
影响因子：
2.5
通讯作者：
Rowley, Anne H.
中科院分区：
文献类型：
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作者：
Rowley, Anne H.
尽管川崎病 (KD) 的病因在很大程度上尚不清楚，但大量临床、流行病学、免疫学、病理学和超微结构证据表明，传染原会引发连锁反应，从而导致该疾病。然而，这种难以捉摸的传染原目前仍未被识别。用于识别组织样本中微生物核酸和蛋白质的越来越灵敏的分子方法不断迅速出现，这些方法一旦可用，就应该用于川崎病病因学的研究。确定这种神秘疾病的病因仍然是该领域最重要的研究目标，实现这一目标是改善这种潜在致命儿童疾病的诊断、治疗和预防的最佳手段。
Although the etiology of Kawasaki disease (KD) is largely unknown, a large body of clinical, epidemiologic, immunologic, pathologic and ultrastructural evidence suggests that an infectious agent triggers a cascade that causes the illness. However, this elusive infectious agent remains unidentified at present. Increasingly sensitive molecular methods for identifying microbial nucleic acids and proteins in tissue samples continue to rapidly emerge, and these methods should be utilized in studies on KD etiology as they become available. Identifying the etiology of this enigmatic disease remains the single most important research goal in the field, and accomplishing this goal is the best means to improve diagnosis, treatment and prevention of this potentially fatal childhood disease.