METABOLIC ADAPTATIONS INDUCED BY LONG-TERM FASTING IN QUAILS
METABOLIC ADAPTATIONS INDUCED BY LONG-TERM FASTING IN QUAILS
复制标题
DOI：
10.1016/0300-9629(95)00022-y
复制
发表时间：
1995-07-01
影响因子：
2.3
通讯作者：
LINDER, C
中科院分区：
文献类型：
--
作者：
SARTORI, DRS;MIGLIORINI, RH;LINDER, C
在长达 21 天不进食后，成年雄性鹌鹑 (Coturnix coturnix japonica) 的体重下降了约 45%（100-150 克）。与自然快速适应和较大的鸟类一样，鹌鹑在长期禁食期间发现了三个阶段。第一阶段持续2-3天，其特点是体重减轻速度和高脂肪动员速度迅速下降。第二阶段较长，其特点是体重减轻和氮排泄率缓慢而稳定地下降。第三个（关键）时期的特点是体重减轻和氮排泄率突然增加。尽管鹌鹑体型较小，但第二阶段的持续时间相对较长，这对于研究这一关键适应时期发生的几种代谢事件之间的关系具有明显的优势。此外，还可以精确确定第三阶段的开始时间。血糖、血浆 FFA 和三酰甘油水平以及肝脏和胴体脂质含量的变化与其他鸟类中发现的相似。因此，鹌鹑似乎是研究非禁食鸟类对长期食物剥夺的代谢调整所涉及的生化机制的合适模型。
After up to 21 days without food, adult male quails (Coturnix coturnix japonica) lost about 45% of the initial body weight (100-150 g). As in naturally fast-adapted and larger birds, three phases were identified during prolonged fasting in quails. Phase I lasted 2-3 days and was characterized by a rapid decrease in the rate of body weight loss and high fat mobilization. Phase II was longer and characterized by a slow and steady decline in the rates of body weight loss and of nitrogen excretion. The third (critical) period was marked by an abrupt increase in the rates of body weight loss and of nitrogen excretion. Despite their small size, the duration of phase II in quails was relatively long, a clear advantage for the study of the relationships between the several metabolic events that occur during this crucial adaptative period. Also, the beginning of phase III could be precisely determined. Changes in blood glucose, plasma FFA and triacylglycerols levels, as well as in liver and carcass lipid content were similar to those found in other species of birds. Therefore, quails seem to be a suitable model to investigate the biochemical mechanisms involved in the metabolic adjustments to prolonged food deprivation in non fasting-adapted birds.