Association of uric acid with traditional inflammatory factors in stroke
Association of uric acid with traditional inflammatory factors in stroke
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DOI：
10.3109/00207454.2015.1015723
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发表时间：
2016-04
影响因子：
2.2
通讯作者：
Aiqun Zhu;T. Zou;Guangzhong Xiong;Jingping Zhang
中科院分区：
文献类型：
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作者：
Aiqun Zhu;T. Zou;Guangzhong Xiong;Jingping Zhang
尿酸（UA）在引起炎症的氧化应激中起重要作用。我们评估了524例脑卒中患者UA与中性粒细胞比率、白色血细胞（WBC）计数和血脂之间的关系。中性粒细胞比值>70%的脑卒中患者UA水平显著低于中性粒细胞比值≤70%的患者（p < 0.05）。根据UA四分位数，UA 1级组（≤214.10 μmol/L）的中性粒细胞比率、白细胞计数和高密度脂蛋白胆固醇显著高于其他UA分级组。逐步回归分析结果显示尿酸水平与中性粒细胞比率呈负相关（B ± SE = −1.11 ± 0.35），高密度脂蛋白胆固醇（B ± SE = −46.18 ± 14.17）、总胆固醇（B ± SE = 9.82 ± 3.66）、血尿素氮（B ± SE = 6.30 ± 1.73）和肌酐（B ± SE = 0.63 ± 0.10）。在脑卒中相关炎症中，低血尿酸与中性粒细胞比值之间存在相关性，其原因有待进一步研究。
Uric acid (UA) plays an important role in the oxidant stress that causes inflammation. We assessed the association between UA and neutrophil ratio, white blood cell (WBC) count and blood lipid in 524 patients admitted with stroke. Stroke patients with a neutrophil ratio >70% displayed significantly lower UA levels than those with a neutrophil ratio ≤70% (p < 0.05). According to UA quartiles, neutrophil ratio, WBC count, and high-density lipoprotein cholesterol in the UA grade 1 group (≤214.10 μmol/L) were significantly increased over those in other UA grade groups. The results of stepwise regression analysis found that UA levels were inversely associated with neutrophil ratios (B ± SE = −1.11 ± 0.35), high-density lipoprotein cholesterol (B ± SE = −46.18 ± 14.17), total cholesterol (B ± SE = 9.82 ± 3.66), blood urea nitrogen (B ± SE = 6.30 ± 1.73), and creatinine (B ± SE = 0.63 ± 0.10). There is a correlationship between lower serum uric acid with neutrophil ratios in inflammation associated with stroke and the reasons need to be investigated further.